| Clinical and electrophysiological effects of apomorphine in Parkinson's disease patients are not paralleled by amino acid release changes: a microdialysis study. | |
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MedLine Citation:
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PMID: 11396272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a microdialysis investigation of extracellular amino acid (glutamate and GABA) concentrations during sterotaxic neurosurgery (the implantation of permanent electrodes in the internal globus pallidus (GPi) or subthalamic nucleus (STN) for deep brain stimulation in advanced Parkinson's disease (PD) patients, after prolonged therapy wash-out). Electrophysiological single unit recordings and perioperative clinical status assessments were also performed. Amino acid levels were measured in the GPi and GPe (external globus pallidus) of three PD patients and in the STN of another three PD patients. Stable basal release values of the examined amino acids were obtained within one hour. In clinical "off" state, the basal levels of GABA in the GPi were double those in the GPe in all the three patients. This finding could represent a biochemical marker for GPi target identification in PD surgery. Acute subcutaneous apomorphine administration induced electrophysiological changes and clinical amelioration but did not change amino acid concentrations. This result could be due to methodological limitations of the microdialysis technique. Alternatively, it could suggest that the clinical effects of acute apomorphine might also be mediated by direct activation of dopaminergic receptors located in the output nuclei. |
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Authors:
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E Fedele; A Stefani; A Bassi; O Pepicelli; M G Altibrandi; S Frasca; P Giacomini; P Stanzione; P Mazzone |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Functional neurology Volume: 16 ISSN: 0393-5264 ISO Abbreviation: Funct. Neurol. Publication Date: 2001 Jan-Mar |
Date Detail:
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Created Date: 2001-06-08 Completed Date: 2002-01-07 Revised Date: 2012-02-22 |
Medline Journal Info:
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Nlm Unique ID: 8707746 Medline TA: Funct Neurol Country: Italy |
Other Details:
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Languages: eng Pagination: 57-66 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Section of Pharmacology and Toxicology, University of Genoa. fedele@pharmatox.unige.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amino Acids / metabolism* Apomorphine / administration & dosage*, adverse effects Brain / drug effects, physiopathology Brain Mapping Electrodes, Implanted Electroencephalography / drug effects* Female Globus Pallidus / drug effects, physiopathology Glutamic Acid / metabolism Humans Male Microdialysis Middle Aged Neurologic Examination / drug effects Parkinson Disease / drug therapy*, physiopathology Subthalamic Nucleus / drug effects, physiopathology gamma-Aminobutyric Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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E.C0998//Telethon |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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