Document Detail

Clinical and electroencephalographic correlates in Rasmussen's encephalitis.
MedLine Citation:
PMID:  9048671     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Rasmussen's encephalitis (RE) is a progressive childhood disease characterized by unilateral brain dysfunction, seizures, and inflammatory histopathology. Converging lines of evidence suggest that an autoimmune process is important in the pathogenesis of RE. METHODS: Two patients with pathologically confirmed RE and increased levels of circulating glutamate receptor subunit (GluR3) antibodies were studied prospectively before, during, and after trials of plasmapheresis (PEX) and other immunomodulation. Frequency, duration, and intensity of clinical seizures were directly correlated with the abundance of interictal epileptiform activity on serial EEGs. RESULTS: Serial EEGs in these patients suggest that early in the course of RE interictal epileptiform activity is localized to the affected hemisphere and that disease progression is associated with increasingly frequent bilaterally synchronous and contralateral epileptiform activity. CONCLUSIONS: The clinical and EEG parameters of epileptogenesis were transiently diminished by PEX, which suggests that circulating factors induce dose-dependent, reversible epileptogenic effects in some patients with RE.
P I Andrews; J O McNamara; D V Lewis
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  38     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Department of Pediatrics, Duke Center for the Advanced Study of Epilepsy, Durham, North Carolina, USA.
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MeSH Terms
Autoimmune Diseases / diagnosis
Brain / physiopathology
Child, Preschool
Chronic Disease
Disease Progression
Encephalitis / diagnosis*,  physiopathology,  therapy
Epilepsies, Partial / diagnosis*,  physiopathology,  therapy
Functional Laterality / physiology
Receptors, Glutamate / immunology,  physiology
Reg. No./Substance:
0/Receptors, Glutamate

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