Document Detail

Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy.
MedLine Citation:
PMID:  18495738     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Copper deficiency is an increasingly recognised cause of neurological impairment. This retrospective review highlights clinical and electrodiagnostic findings in patients diagnosed at our institution with copper deficiency. METHODS: Clinical, radiographic and electrodiagnostic findings were reviewed in patients with evidence of copper deficiency. Patients with other potential causes of myelopathy or neuropathy were excluded. RESULTS: The predominant clinical feature in all six patients was a sensory ataxia, resulting in marked gait unsteadiness. Nerve conduction studies and needle EMG were performed in all patients and revealed a mild to moderate distal, axonal, sensorimotor peripheral neuropathy. Median and tibial somatosensory evoked potentials were abnormal in all five patients in which it was performed, showing impaired conduction in central or proximal peripheral somatosensory pathways. CONCLUSIONS: This pattern of electrodiagnostic findings suggests that impairment in somatosensory pathways demonstrated by somatosensory evoked potential testing is the main cause of the sensory ataxia in patients with copper deficiency.
B P Goodman; E P Bosch; M A Ross; C Hoffman-Snyder; D D Dodick; B E Smith
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Publication Detail:
Type:  Journal Article     Date:  2008-05-21
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  80     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  524-7     Citation Subset:  IM    
Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA.
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MeSH Terms
Copper / deficiency*
Evoked Potentials, Somatosensory / physiology
Gait Disorders, Neurologic / physiopathology
Magnetic Resonance Imaging
Middle Aged
Muscle, Skeletal / physiopathology
Neural Conduction / physiology
Neurologic Examination
Peripheral Nervous System Diseases / diagnosis*,  pathology,  physiopathology
Retrospective Studies
Spinal Cord Diseases / diagnosis*,  pathology,  physiopathology
Reg. No./Substance:

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