Document Detail

Clinical and electro-clinical classification of epileptic seizure in west Uganda.
MedLine Citation:
PMID:  11204726     Owner:  NLM     Status:  MEDLINE    
When compared to that of industralised countries, the prevalence of epilepsy in developing countries has generally been found to be higher and in some areas extremely high rates of up to 57 cases per 1000 inhabitants have been reported. The reasons for this difference are still widely unknown and detailed epidemiological as well as clinical data are scarce, especially from rural Africa. The present study was conducted in western Uganda, in an area of high epilepsy prevalence, known to be endemic for onchocerciasis. The seizures of all 91 epilepsy patients diagnosed in this area over the period of two years were classified according to the criteria of the International League against Epilepsy. Based on seizure description alone, the predominant seizure was classified as generalised in 57 patients (63%), as partial in 22 (24%) and unclassified in 12 (13%). An EEG record was analysed in 55 out of 91 patients, showing focal epileptiform activity (EA) in 12, multifocal EA in 9 and primarily generalised EA in 6 patients. When in addition to clinical information, the EEG results in the 27 patients with EA were taken in consideration for seizure classification, the proportion of partial seizures increased to 78% (n = 21); inversely the proportion of generalised seizures fell to 22% (n = 6). The predominance of partial seizures would be compatible with a localised brain lesion as a frequent cause for epileptic seizures in the study area. The findings further corroborate recent observations from several African countries of an association between epilepsy and onchocerciasis.
C Kaiser; C Benninger; G Asaba; C Mugisa; G Kabagambe; W Kipp; D Rating
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin de la Société de pathologie exotique (1990)     Volume:  93     ISSN:  0037-9085     ISO Abbreviation:  Bull Soc Pathol Exot     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-06     Completed Date:  2001-03-01     Revised Date:  2005-09-19    
Medline Journal Info:
Nlm Unique ID:  9212564     Medline TA:  Bull Soc Pathol Exot     Country:  France    
Other Details:
Languages:  eng     Pagination:  255-9     Citation Subset:  IM    
Department of Pediatric Neurology, University Children's Hospital, Im Neuenheimer, Feld 150, 69120 Heidelberg, Germany.
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MeSH Terms
Age Distribution
Case-Control Studies
Child, Preschool
Developing Countries
Endemic Diseases / statistics & numerical data
Epilepsy / classification*,  diagnosis*,  epidemiology,  etiology
Middle Aged
Onchocerciasis / complications,  epidemiology
Population Surveillance
Risk Factors
Rural Health / statistics & numerical data
Seizures / classification*,  diagnosis*,  epidemiology,  etiology
Sex Distribution
Uganda / epidemiology

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