Document Detail


Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience.
MedLine Citation:
PMID:  17959327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers. RESULTS: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to <100% reduction in seizure frequency; 15 (24.2%) had >50% to <75% reduction in seizure frequency; 6 (9.7%) had >0% to <50% reduction in seizure frequency, and 24 (38.7%) had no seizure reduction. Seizure outcomes were not related to seizure types or etiologies. Adverse events included somnolence and anorexia, but all were transient and successfully managed by careful follow-up. CONCLUSION: Our results indicate that adjunctive treatment with ZNS is safe and effective in pediatric LGS patients.
Authors:
Su Jeong You; Hoon-Chul Kang; Heung Dong Kim; Hyun Sug Lee; Tae-Sung Ko
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2007-10-23
Journal Detail:
Title:  Brain & development     Volume:  30     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Epilepsy Center, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / administration & dosage*,  adverse effects
Child
Child, Preschool
Epilepsy / drug therapy*
Female
Follow-Up Studies
Humans
Infant
Isoxazoles / administration & dosage*,  adverse effects
Korea
Male
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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