Document Detail

Clinical efficacy of sublingual captopril in the treatment of hypertensive urgency.
MedLine Citation:
PMID:  19421685     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: This study aimed to evaluate the response rate, clinical efficacy and onset of action of sublingual captopril in patients diagnosed with hypertensive urgency. METHODS: In this cross-sectional study, 101 (67 female and 34 male) patients with a diagnosis of hypertensive urgency (systolic pressure greater than or equal to 180 mmHg and/or diastolic pressure greater than or equal to 110 mmHg, and no findings of target organ damage) were included. Sublingual captopril (25 mg) was administered and the blood pressure was measured during a follow-up period of 120 minutes. RESULTS: After 60 minutes, an ideal decrease (25 percent of the initial blood pressure) was detected in 54 patients (53.5 percent). An additional 25 mg of sublingual captopril was administered to the remaining 47 patients (46.5 percent). Of these, 19 (18.8 percent) did not respond even to the second dose of sublingual captopril. These non-responders consisted of patients who were taking multidrug antihypertensive regimens before presentation due to hypertensive urgency. No serious side effect was recorded during the study period. CONCLUSION: Sublingual captopril can be used as an effective, easily applicable and safe treatment in the management of hypertensive urgency for 120 minutes for those who do not receive multidrug antihypertensive regimens.
H Kazerani; B Hajimoradi; A Amini; M H Naseri; Y Moharamzad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  50     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  400-2     Citation Subset:  IM    
Department of Cardiology, Imam Ali Hospital, Kermanshah University of Medical Sciences, Shahid Beheshti Boulevard, Kermanshah 67158-47145, Iran.
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MeSH Terms
Administration, Sublingual
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Pressure / drug effects
Captopril / administration & dosage*,  adverse effects
Cross-Sectional Studies
Dose-Response Relationship, Drug
Drug Therapy, Combination
Hypertension / drug therapy*
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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