Document Detail


Clinical efficacy of a triclosan/copolymer pre-brush rinse.
MedLine Citation:
PMID:  1524687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A five-day, double-blind parallel clinical study was conducted to determine the effect on plaque removal of a pre-brush rinse containing 0.03 triclosan (Irgacare MP, Ciba-Geigy Corp.) and 0.125% of a copolymer of methoxyethylene and maleic acid (Gantrez, GAF Corp.), as compared to a matching placebo pre-brush rinse. One hundred eleven subjects were stratified into two balanced groups according to baseline Quigley-Hein Plaque Index scores. Each group was randomly assigned to use either the triclosan/copolymer pre-brush rinse or the matching placebo pre-brush rinse. In order to determine plaque removal efficacy of the pre-brush rinses, subjects rinsed their mouths twice daily (mornings and evenings) for one minute with 15 ml of their assigned pre-brush rinse. Immediately after rinsing, subjects brushed their teeth for 30 seconds with a commercially available dentifrice containing 0.76% sodium monofluorophosphate and a soft-bristled toothbrush. The morning rinsing/brushing procedure was done under supervision at the clinical facility. The evening rinsing/brushing procedure was done at home. After five days' use of their assigned pre-brush rinse and toothbrushing, subjects were evaluated by the dental examiner for residual plaque using the modified Quigley-Hein Plaque Index scoring procedure. When mean five-day Quigley-Hein Plaque Index scores were compared for both groups, the triclosan/copolymer pre-brush rinse removed 22.54% more plaque from all surfaces of the teeth than the matching placebo pre-brush rinse. When mean Quigley-Hein Plaque Index decrements (the difference between baseline and five-day Quigley-Hein Plaque Index scores) were compared for both groups, the triclosan/copolymer pre-brush rinse removed more than twice as much plaque from all surfaces of the teeth than the matching placebo pre-brush rinse (33.99% efficacy versus 15.19% efficacy). When mean five-day Plaque Severity Index scores were compared for both groups, the triclosan/copolymer pre-brush rinse removed 46.15% more plaque from the "more difficult to brush" surfaces of the teeth than the matching placebo pre-brush rinse. rinse.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R R Lobene; S M Singh; L Garia; M E Petrone; A R Volpe; P Chaknis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of clinical dentistry     Volume:  3     ISSN:  0895-8831     ISO Abbreviation:  J Clin Dent     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904411     Medline TA:  J Clin Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-8     Citation Subset:  D    
Affiliation:
Forsyth Dental Center, Research Institute.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Dental Plaque / prevention & control*
Dental Plaque Index
Double-Blind Method
Female
Humans
Male
Maleates / therapeutic use
Mouthwashes / therapeutic use*
Polyvinyls / therapeutic use
Triclosan / therapeutic use*
Chemical
Reg. No./Substance:
0/Maleates; 0/Mouthwashes; 0/Polyvinyls; 0/polyvinylmethoxyethylene-maleic anhydride copolymer; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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