Document Detail

Clinical efficacy of intravenous immunoglobulin in patients with severe inflammatory chest disease and IgG3 subclass deficiency.
MedLine Citation:
PMID:  1863998     Owner:  NLM     Status:  MEDLINE    
To investigate the efficacy of i.v. IgG treatment in pediatric patients with inflammatory lung disease, a prospective, controlled clinical trial was carried out over a 2-year study period. Patients were enrolled on the basis of severe clinical symptomatology. After 1 year of conventional treatment, the patients received 400 mg/kg per month of an i.v. IgG product containing only trace amounts of IgG3 in addition to their regular treatment throughout the second year. Significant clinical improvement, as documented by duration of hospital stay (first year 27.8 days, second year 4.9 days), use of antibiotics (132.8 versus 30.9 days) and use of steroids (21.4 versus 0.7 days) could be observed. Data obtained on a subgroup of patients with IgG3 deficiency were analysed separately. These results indicate that patients with severe chest disease who have IgG3 deficiency will also benefit from i.v. IgG treatment. The mode of action cannot be attributed to replacement of the respective isotypes, but is probably due to the effect of i.v. IgG in preventing repeated viral infections.
E Bernatowska-Matuszkiewicz; M Pac; H Skopcynska; M Pum; M M Eibl
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  85     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Department of Clinical Immunology, Children's Memorial Hospital, Warsaw, Poland.
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MeSH Terms
Child, Preschool
Dysgammaglobulinemia / complications,  pathology,  therapy*
IgG Deficiency*
Immunization, Passive*
Immunoglobulin G / analysis,  therapeutic use*
Immunoglobulin M / analysis
Injections, Intravenous
Lung Diseases / complications,  pathology,  therapy*
Prospective Studies
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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