Document Detail


Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin transporter gene on childhood autism.
MedLine Citation:
PMID:  16119478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the correlation between response to fluvoxamine and serotonin transporter gene promoter region polymorphism (5-HTTLPR). Eighteen children with autistic disorder completed a 12-week double-blind, placebo-controlled, randomized crossover study of fluvoxamine. Behavioral assessments were obtained before and at 12 weeks of treatment. 5-HTTLPR (long (l) or short(s)), was analyzed by the PCR method. Ten out of 18 patients responded to fluvoxamine treatment; allele type analysis revealed that clinical global effectiveness was noted significantly more in the l allele than in the s allele. However, with respect to language use, a significant effectiveness was noted in the s allele. 5-HTTLPR may influence the individual responses to fluvoxamine administration.
Authors:
Yoko Sugie; Hideo Sugie; Tokiko Fukuda; Masataka Ito; Yumiko Sasada; Mutsumi Nakabayashi; Kazunobu Fukashiro; Takehiko Ohzeki
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  35     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2005-12-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan. y-sugie@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alleles
Autistic Disorder / drug therapy*,  genetics*
Child
Child, Preschool
Cross-Over Studies
Double-Blind Method
Fluvoxamine / therapeutic use*
Gene Expression
Genotype
Humans
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Serotonin Plasma Membrane Transport Proteins / genetics*
Serotonin Uptake Inhibitors / therapeutic use*
Chemical
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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