| Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin transporter gene on childhood autism. | |
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MedLine Citation:
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PMID: 16119478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the correlation between response to fluvoxamine and serotonin transporter gene promoter region polymorphism (5-HTTLPR). Eighteen children with autistic disorder completed a 12-week double-blind, placebo-controlled, randomized crossover study of fluvoxamine. Behavioral assessments were obtained before and at 12 weeks of treatment. 5-HTTLPR (long (l) or short(s)), was analyzed by the PCR method. Ten out of 18 patients responded to fluvoxamine treatment; allele type analysis revealed that clinical global effectiveness was noted significantly more in the l allele than in the s allele. However, with respect to language use, a significant effectiveness was noted in the s allele. 5-HTTLPR may influence the individual responses to fluvoxamine administration. |
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Authors:
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Yoko Sugie; Hideo Sugie; Tokiko Fukuda; Masataka Ito; Yumiko Sasada; Mutsumi Nakabayashi; Kazunobu Fukashiro; Takehiko Ohzeki |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: 35 ISSN: 0162-3257 ISO Abbreviation: J Autism Dev Disord Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-25 Completed Date: 2005-12-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 377-85 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan. y-sugie@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Autistic Disorder / drug therapy*, genetics* Child Child, Preschool Cross-Over Studies Double-Blind Method Fluvoxamine / therapeutic use* Gene Expression Genotype Humans Polymorphism, Genetic / genetics* Promoter Regions, Genetic / genetics Serotonin Plasma Membrane Transport Proteins / genetics* Serotonin Uptake Inhibitors / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Plasma Membrane Transport Proteins; 0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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