Document Detail

Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin transporter gene on childhood autism.
MedLine Citation:
PMID:  16119478     Owner:  NLM     Status:  MEDLINE    
We studied the correlation between response to fluvoxamine and serotonin transporter gene promoter region polymorphism (5-HTTLPR). Eighteen children with autistic disorder completed a 12-week double-blind, placebo-controlled, randomized crossover study of fluvoxamine. Behavioral assessments were obtained before and at 12 weeks of treatment. 5-HTTLPR (long (l) or short(s)), was analyzed by the PCR method. Ten out of 18 patients responded to fluvoxamine treatment; allele type analysis revealed that clinical global effectiveness was noted significantly more in the l allele than in the s allele. However, with respect to language use, a significant effectiveness was noted in the s allele. 5-HTTLPR may influence the individual responses to fluvoxamine administration.
Yoko Sugie; Hideo Sugie; Tokiko Fukuda; Masataka Ito; Yumiko Sasada; Mutsumi Nakabayashi; Kazunobu Fukashiro; Takehiko Ohzeki
Related Documents :
17548158 - Serotonin transporter gene (5-htt): association analysis with temporal lobe epilepsy.
25140878 - Elevated heart rate triggers action potential alternans and sudden death. translational...
24623178 - Dissecting the causal genetic mechanisms of coronary heart disease.
12904838 - Searching for osteoporosis genes in the post-genome era: progress and challenges.
19447378 - Mapping qtls for heading synchrony in a doubled haploid population of rice in two envir...
23051628 - Fibrosis-associated single-nucleotide polymorphisms in tgfΒ1 and cav1 are not associat...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  35     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2005-12-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-85     Citation Subset:  IM    
Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autistic Disorder / drug therapy*,  genetics*
Child, Preschool
Cross-Over Studies
Double-Blind Method
Fluvoxamine / therapeutic use*
Gene Expression
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Serotonin Plasma Membrane Transport Proteins / genetics*
Serotonin Uptake Inhibitors / therapeutic use*
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Developmental change in neutral processing of words by children with autism.
Next Document:  Retrospective study of quetiapine in children and adolescents with pervasive developmental disorders...