Document Detail

Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk.
MedLine Citation:
PMID:  21214707     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To evaluate the clinical efficacy and cardiorespiratory effects of alfaxalone as an anaesthetic induction agent in dogs with moderate to severe systemic disease.
STUDY DESIGN: Randomized prospective clinical study.
ANIMALS: Forty dogs of physical status ASA III-V referred for various surgical procedures.
METHODS: Dogs were pre-medicated with intramuscular methadone (0.2 mg kg(-1) ) and allocated randomly to one of two treatment groups for induction of anaesthesia: alfaxalone (ALF) 1-2 mg kg(-1) administered intravenously (IV) over 60 seconds or fentanyl 5 μg kg(-1) with diazepam 0.2 mg kg(-1) ± propofol 1-2 mg kg(-1) (FDP) IV to allow endotracheal intubation. Anaesthesia was maintained with isoflurane in oxygen and fentanyl infusion following both treatments. All dogs were mechanically ventilated to maintain normocapnia. Systolic blood pressure (SAP) was measured by Doppler ultrasound before and immediately after anaesthetic induction, but before isoflurane administration. Parameters recorded every 5 minutes throughout subsequent anaesthesia were heart and respiratory rates, end-tidal partial pressure of carbon dioxide and isoflurane, oxygen saturation of haemoglobin and invasive systolic, diastolic and mean arterial blood pressure. Quality of anaesthetic induction and recovery were recorded. Continuous variables were assessed for normality and analyzed with the Mann Whitney U test. Repeated measures were log transformed and analyzed with repeated measures anova (p<0.05).
RESULTS: Treatment groups were similar for continuous and categorical data. Anaesthetic induction quality was good following both treatments. Pre-induction and post-induction systolic blood pressure did not differ between treatments and there was no significant change after induction. The parameters measured throughout the subsequent anaesthetic procedures did not differ between treatments. Quality of recovery was very, quite or moderately smooth.
CONCLUSIONS AND CLINICAL RELEVANCE: Induction of anaesthesia with alfaxalone resulted in similar cardiorespiratory effects when compared to the fentanyl-diazepam-propofol combination and is a clinically acceptable induction agent in sick dogs.
Evdokia Psatha; Hatim I K Alibhai; Angeles Jimenez-Lozano; Elizabeth Armitage-Chan; David C Brodbelt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  38     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-36     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Veterinary Anaesthesia and Analgesia © 2011 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.
Queen Mother Hospital, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, UK.
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