Document Detail


Clinical efficacy and biocompatibility of three different leukocyte and fat removal filters during cardiac surgery.
MedLine Citation:
PMID:  16734597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activated leukocytes and fat particles are associated with organ injury after a cardiac surgery. Filters are currently used to remove either leukocytes or fat particles. A novel approach with a filter that combines leukocyte and fat removal might be clinically useful. As it is not known which type of filter has a good and safe performance in both leukocyte and fat removal, we measured in this study the leukocyte and fat removal properties and the biocompatibility of three different filters. We used six Pall RS1 (Pall, Portsmouth, England) leukocyte removal filters, six Pall LipiGuard fat removal filters, and six Fresenius Biofil 02 (Fresenius, Emmer-Compascuum, The Netherlands) leukocyte removal filters and measured the passage times of 500 and 1000 mL of residual heart-lung machine blood. We determined the circulating leukocyte and platelet counts, and total hemoglobin, triglyceride, and free fatty acid concentration after the filters. In addition, we measured free hemoglobin, plasma elastase (Merck, Darmstadt, Germany), and complement C5-9 (Quidel, San Diego, CA, U.S.A.) to assess the biocompatibility of the filters. The circulating fat particles were calculated with an automated hematology analyzer. The passage time for the blood was shortest for the Biofil filter (P = 0.02, analysis of variance). The total leukocyte counts (P = 0.04) and fat particles (P = 0.02) were higher after the LipiGuard filter. This filter also had a higher increase in free hemoglobin concentration (P = 0.03). We conclude that the leukocyte removal filters were superior to the fat removal filter both in leukocyte and fat removal.
Authors:
Adrianus J de Vries; Wytze J Vermeijden; Y John Gu; J Ans M Hagenaars; Willem van Oeveren
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Artificial organs     Volume:  30     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands. a.j.de.vries@anest.umcg.nl
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Component Removal / instrumentation*,  methods
Cardiopulmonary Bypass*
Complement System Proteins / analysis
Fats*
Fatty Acids / blood
Heart-Lung Machine
Hemoglobins / analysis
Humans
Leukocyte Count
Leukocyte Reduction Procedures / instrumentation,  methods
Male
Materials Testing*
Micropore Filters*
Middle Aged
Pancreatic Elastase / blood
Platelet Count
Prospective Studies
Chemical
Reg. No./Substance:
0/Fats; 0/Fatty Acids; 0/Hemoglobins; 9007-36-7/Complement System Proteins; EC 3.4.21.36/Pancreatic Elastase

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