Document Detail


Clinical efficacy of an anticalculus fluoride dentifrice containing triclosan and a copolymer: a 6-month study.
MedLine Citation:
PMID:  1854445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 6-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base, as compared to a placebo dentifrice containing 0.243% sodium fluoride in a silica base. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold calculus index scores that were obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either the fluoride/triclosan/copolymer dentifrice or the placebo dentifrice. Seventy adult male and female subjects completed the entire 6-month study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at the 99% level of confidence. The results after 6 months indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 36.27% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction was significant at the 99% level of confidence.
Authors:
R R Lobene; G W Battista; D M Petrone; A R Volpe; M E Petrone
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of dentistry     Volume:  4     ISSN:  0894-8275     ISO Abbreviation:  Am J Dent     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806701     Medline TA:  Am J Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-5     Citation Subset:  D    
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Dental Calculus / prevention & control*
Dentifrices*
Double-Blind Method
Female
Follow-Up Studies
Humans
Male
Maleates / administration & dosage*
Polyvinyls / administration & dosage*
Sodium Fluoride / administration & dosage
Triclosan / administration & dosage*
Chemical
Reg. No./Substance:
0/Dentifrices; 0/Maleates; 0/Polyvinyls; 0/polyvinylmethoxyethylene-maleic anhydride copolymer; 3380-34-5/Triclosan; 7681-49-4/Sodium Fluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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