Document Detail


Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis.
MedLine Citation:
PMID:  12622929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis. METHODS: Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1 - 4 years after the cessation of therapy. RESULTS: At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.1%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg.kg(-1).d(-1) for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results. CONCLUSIONS: AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.
Authors:
Junjie Chai; Menghebat; Wei Jiao; Deyu Sun; Bin Liang; Jincao Shi; Cheng Fu; Xiong Li; Yiding Mao; Xiuling Wang; Dolikun; Guliber; Yanchun Wang; Fanghua Gao; Shuhua Xiao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1809-13     Citation Subset:  IM    
Affiliation:
Xinjiang Institute for Endemic Diseases Control and Research, Urumqi 830002, China. jchai@xj.cninfo.net
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Albendazole / administration & dosage*,  adverse effects
Child
Child, Preschool
Echinococcosis, Hepatic / drug therapy*
Emulsions
Female
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Emulsions; 54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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