| Clinical effects and utility of intracoronary diltiazem. | |
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MedLine Citation:
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PMID: 7497500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery spasm is a known complication of coronary interventions, for which intracoronary nitroglycerin (ICN) is the treatment of choice. Some forms of intense spasm are resistant to ICN. Calcium channel antagonists are also known to be effective for coronary artery spasm, including nitroglycerin-resistant spasm. Here we describe a protocol for the clinical use of intracoronary diltiazem (ICD). By this protocol, ICD can be safely given without disturbing the clinical status of patients. ICD (2.5 mg) given slowly over 1 minute produced no vasodilitation of normal vessel segments but did produce significant dilatation of stenotic segments above and beyond the effects of nitrates. Mean minimum lumen diameter increased 18%, from 0.89 +/- 0.06 mm to 1.06 +/- 0.07 mm (mean +/- SEM, P < 0.001). ICD produced clinically insignificant changes in systolic blood pressure, diastolic blood pressure, heart rate, and PR, QRS, and QT intervals. This protocol has been employed to safely use ICD to relieve both nitroglycerin-resistant epicardial artery spasm and nitroglycerin-resistant distal microvascular spasm (the no-reflow phenomenon). |
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Authors:
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M E McIvor; C Undemir; J Lawson; J Reddinger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 35 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-01-18 Completed Date: 1996-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 287-91, discussion 92-3 Citation Subset: IM |
Affiliation:
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All Children's Hospital, St. Petersburg, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Protocols Coronary Angiography Coronary Vasospasm / drug therapy*, physiopathology, radiography Diltiazem / administration & dosage* Electrocardiography Hemodynamics / drug effects Humans Infusions, Intra-Arterial Nitroglycerin / administration & dosage Pilot Projects Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 42399-41-7/Diltiazem; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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