Document Detail


Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?
MedLine Citation:
PMID:  23943728     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF) Methodology: In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months` antibiotic nasal irrigations was assessed in 106 CF patients.
RESULTS: One year after sinus surgery, the prevalence of intermittently colonised patients had decreased by 38%, while the prevalence of non-colonised patients had increased by 150%. The frequency of pulmonary samples with CF pathogens was reduced after surgery. Specific IgG against P. aeruginosa decreased after six months. Additionally, the self reported symptoms of chronic rhinosinusitis and quality of life improved.
CONCLUSION: Combined sinus surgery and postoperative systemic and topical antibiotic treatment significantly reduced the fre- quency of pulmonary samples positive for CF pathogens in the first year after sinus surgery.
Authors:
K Aanaes; H K Johansen; M Skov; F F Buchvald; T Hjuler; T Pressler; N Hoiby; K G Nielsen; C Von Buchwald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  51     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  222-30     Citation Subset:  IM    
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