Document Detail

Clinical effects of isoflurane and sevoflurane in lambs.
MedLine Citation:
PMID:  22524433     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare isoflurane and sevoflurane in lambs undergoing prolonged anaesthesia for spinal surgery.
STUDY DESIGN: Prospective randomised clinical study.
ANIMALS: Eighteen Scottish blackface lambs 3-6 weeks of age and weighing 10-17 kg.
METHODS: After intramuscular medetomidine, anaesthesia was induced and maintained with either isoflurane (group I) or sevoflurane (group S) delivered in oxygen. Meloxicam, morphine, a constant rate infusion of ketamine and atracurium were given intravenously (IV) during surgery. Lungs were ventilated to maintain normocapnia. with peak inspiratory pressures of 20-25 cmH(2) O. Ephedrine or dextran 40% was administered when mean arterial pressure (MAP) was <55 mmHg. Intrathecal morphine, and IV meloxicam and edrophonium were injected before recovery. Time to loss of palpebral reflex (TLPR) upon induction, cardiorespiratory variables, time at first swallowing and other movement, tracheal extubation, vocalisation, spontaneous head lifting (>1 minute), reunion with the ewe, and the number of MAP treatments were recorded. Statistical analysis utilised anova, Mann-Whitney, t-test or Pearson's correlation test as relevant. p < 0.05 was considered significant.
RESULTS: End-tidal carbon dioxide (mean ± SD) was significantly lower in group S (5.5 ± 0.6 kPa) than in group I (5.8 ± 0.5 kPa) while MAP (70 ± 11 mmHg) and diastolic arterial blood pressure (60 ± 11 mmHg) were higher in group S than in group I (65 ± 12 and 54 ± 11 mmHg, respectively). No differences were found with TLPR and MAP treatments. Time (median, range) from end of anaesthesia to ewe-lamb reunion was briefer (p = 0.018) in group S (48, 20-63 minutes).
CONCLUSION: Isoflurane and sevoflurane are both suitable for maintaining general anaesthesia in lambs although sevoflurane, as used in this study, allows a more rapid reunion with the ewe.
CLINICAL RELEVANCE: The principal advantage of sevoflurane over isoflurane during prolonged anaesthesia in lambs is a more rapid recovery.
Enzo Vettorato; Gudrun Schöffmann; John G Burke; Alastair J N Gibson; Eddie R Clutton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-04-24
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  39     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2013-01-02     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  495-502     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Veterinary Anaesthesia and Analgesia. © 2012 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.
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MeSH Terms
Anesthesia Recovery Period
Anesthetics, Inhalation / pharmacology*
Behavior, Animal / drug effects
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Grant Support
G0700918//Medical Research Council
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane; CYS9AKD70P/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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