Document Detail

Clinical effectiveness of essential oil-containing dentifrices in controlling oral malodor.
MedLine Citation:
PMID:  11763909     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the efficacy of two essential oil-containing dentifrices in the reduction of human intrinsic oral malodor ("morning bad breath"). MATERIALS AND METHODS: Two clinical trials were conducted which used observer-blind, negative control, parallel designs. To insure a homogeneous test population with similar oral odor characteristics, subjects followed instructions that included toothbrushing with a standard ADA-accepted fluoride dentifrice the night before. On odor evaluation days, subjects refrained from all oral hygiene procedures and from eating or drinking any food or beverage or smoking prior to and during the odor evaluations. Eighty healthy adult subjects in the first trial and 90 in the second trial with qualifying baseline levels of oral malodor participated. Odor ratings of each subject's breath were made by 4-5 trained judges using a nine point hedonic scale, i.e., 1 = most pleasant, 5 = neutral, 9 = most unpleasant. Qualifying subjects were randomly assigned one of two essential oil dentifrices or a negative control dentifrice. Subjects brushed with their assigned dentifrice for 60 s, rinsed with 20 ml of water for 10 s, and received post-treatment hedonic odor ratings at 30, 60, 90, 120, 180, and 240 min. Data were analyzed using an ANCOVA to adjust for baseline scores. RESULTS: The essential oil dentifrices were significantly more effective (P < or = 0.033) than the control in reducing intrinsic oral malodor from 90 to 120 min.
A M Olshan; B E Kohut; J W Vincent; L C Borden; N Delgado; J Qaqish; N C Sharma; J A McGuire
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of dentistry     Volume:  13     ISSN:  0894-8275     ISO Abbreviation:  Am J Dent     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-12-14     Completed Date:  2002-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806701     Medline TA:  Am J Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18C-22C     Citation Subset:  D    
The Warner-Lambert Consumer Healthcare Division of the Warner-Lambert Consumer Group of Pfizer, Morris Plains, NJ 07950, USA.
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MeSH Terms
Analysis of Variance
Anti-Infective Agents, Local / administration & dosage,  therapeutic use*
Citric Acid / administration & dosage,  therapeutic use
Dentifrices / therapeutic use*
Follow-Up Studies
Halitosis / classification,  prevention & control*
Observer Variation
Oils, Volatile / administration & dosage,  therapeutic use*
Single-Blind Method
Statistics as Topic
Treatment Outcome
Zinc Compounds / therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Dentifrices; 0/Oils, Volatile; 0/Zinc Compounds; 77-92-9/Citric Acid

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