Document Detail

Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure.
MedLine Citation:
PMID:  18201352     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Combining phototherapy with topical vitamin D3 analogues is a useful therapy for the treatment of psoriasis by reducing the cumulative UV dose required for clearance of lesions. Experimental investigations demonstrated that calcipotriol is degraded by UV radiation, and suggested that calcipotriol should be applied after phototherapy but not immediately before. METHODS: Calcipotriol or maxacalcitol ointment was topically applied to psoriatic plaques of six patients immediately before or after phototherapy on the right or left side of the body, respectively. RESULTS: Topical application of vitamin D3 analogues either before or after irradiation by psoralen and UVA radiation (PUVA) or narrow-band (NB)-UVB showed exactly similar effects in all patients. CONCLUSION: Therapeutic effects of vitamin D3 analogues are not clinically inactivated by subsequent irradiation with PUVA or NB-UVB phototherapy.
Yuka Adachi; Naoko Uchida; Tomoo Matsuo; Takeshi Horio
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  0905-4383     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  16-8     Citation Subset:  IM    
Department of Dermatology, Kanssai Medical University, Osaka, Japan.
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MeSH Terms
Administration, Cutaneous
Calcitriol / administration & dosage,  analogs & derivatives
Cholecalciferol / administration & dosage*
Combined Modality Therapy
Dermatologic Agents / administration & dosage
Middle Aged
Prospective Studies
Psoriasis / drug therapy*,  pathology,  radiotherapy*
Severity of Illness Index
Treatment Outcome
Ultraviolet Therapy*
Reg. No./Substance:
0/Dermatologic Agents; 103909-75-7/maxacalcitol; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol; 67-97-0/Cholecalciferol

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