| Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure. | |
| | |
MedLine Citation:
|
PMID: 18201352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Combining phototherapy with topical vitamin D3 analogues is a useful therapy for the treatment of psoriasis by reducing the cumulative UV dose required for clearance of lesions. Experimental investigations demonstrated that calcipotriol is degraded by UV radiation, and suggested that calcipotriol should be applied after phototherapy but not immediately before. METHODS: Calcipotriol or maxacalcitol ointment was topically applied to psoriatic plaques of six patients immediately before or after phototherapy on the right or left side of the body, respectively. RESULTS: Topical application of vitamin D3 analogues either before or after irradiation by psoralen and UVA radiation (PUVA) or narrow-band (NB)-UVB showed exactly similar effects in all patients. CONCLUSION: Therapeutic effects of vitamin D3 analogues are not clinically inactivated by subsequent irradiation with PUVA or NB-UVB phototherapy. |
| | |
Authors:
|
Yuka Adachi; Naoko Uchida; Tomoo Matsuo; Takeshi Horio |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Photodermatology, photoimmunology & photomedicine Volume: 24 ISSN: 0905-4383 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-18 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
|
Languages: eng Pagination: 16-8 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Kanssai Medical University, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Adult Calcitriol / administration & dosage, analogs & derivatives Cholecalciferol / administration & dosage* Combined Modality Therapy Dermatologic Agents / administration & dosage Female Humans Male Middle Aged Prospective Studies Psoriasis / drug therapy*, pathology, radiotherapy* Severity of Illness Index Treatment Outcome Ultraviolet Therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Dermatologic Agents; 103909-75-7/maxacalcitol; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol; 67-97-0/Cholecalciferol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Photocontact allergic and phototoxic studies of chlorproethazine.
Next Document: Efficacy of UVA1 phototherapy in 230 patients with various skin diseases.