Document Detail

Clinical effect of a triclosan-containing dentifrice on plaque and gingivitis: a six-month study.
MedLine Citation:
PMID:  1298577     Owner:  NLM     Status:  MEDLINE    
A total of 294 adult male and female subjects completed a 6-month, double-blind clinical trial designed to evaluate the effects of a dentifrice which contained 0.3% triclosan in conjunction with 2% of a methoxyethylene/maleic acid copolymer in a 0.243% sodium fluoride/silica base, relative to a control dentifrice, on supragingival plaque accumulation and gingivitis. Plaque and gingivitis were scored after 3 and 6-month use of the assigned dentifrice. At the end of the study, the triclosan group showed an average reduction, relative to the control group, of 12% in plaque accumulation and 20% in gingivitis. Both were statistically significant at p < or = 0.0001. The effect of the triclosan dentifrice was most pronounced on the more severe manifestations of plaque and gingivitis. The improvement in the gingival parameters at 6-months relative to the control dentifrice was statistically significant at p < or = 0.0001. It was concluded that the twice-daily use of the triclosan-containing dentifrice resulted in significant reduction in supragingival plaque formation and a significant improvement in gingival health without the presence of any extrinsic staining or objectionable taste.
S Mankodi; C Walker; N Conforti; W DeVizio; J J McCool; A R Volpe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical preventive dentistry     Volume:  14     ISSN:  0163-9633     ISO Abbreviation:  Clin Prev Dent     Publication Date:    1992 Nov-Dec
Date Detail:
Created Date:  1993-05-13     Completed Date:  1993-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8004895     Medline TA:  Clin Prev Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-10     Citation Subset:  D    
Clinical Dental Research, Besselaar Clinical Research Unit, West Palm Beach, Florida.
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MeSH Terms
Analysis of Variance
Dental Plaque / prevention & control*
Dental Plaque Index
Dentifrices / therapeutic use*
Double-Blind Method
Gingivitis / drug therapy*
Longitudinal Studies
Maleates / therapeutic use*
Middle Aged
Periodontal Index
Polyvinyls / therapeutic use*
Triclosan / therapeutic use*
Reg. No./Substance:
0/Dentifrices; 0/Maleates; 0/Polyvinyls; 0/polyvinylmethoxyethylene-maleic anhydride copolymer; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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