Document Detail


Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial.
MedLine Citation:
PMID:  20151799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Periodontitis is an inflammatory disease that results in bone resorption creating bony defects, which may cause tooth loss. Various drugs have been studied using local delivery to improve the periodontal health and to achieve periodontal regeneration. Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The present study was designed to investigate the effectiveness of SMV, 1.2 mg, in an indigenously prepared biodegradable controlled-release gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. METHODS: Sixty patients were categorized into two treatment groups: SRP plus placebo (group 1) and SRP plus SMV, 1.2 mg (group 2). Clinical parameters were recorded at baseline before SRP and at 1, 2, 4, and 6 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL). At baseline and after 6 months, radiologic assessment of intrabony defect (IBD) fill was done using computer-aided software. The mean concentration of SMV in gingival crevicular fluid was estimated by reverse-phase high-performance liquid chromatography. RESULTS: All subjects tolerated the drug, without any postapplication inflammation. Both therapies resulted in significant improvements. The decrease in mSBI score at 6 months was greater in group 2 (2.3267 +/- 0.8017) compared to group 1 (0.5033 +/- 0.6815). The mean decrease in PD from baseline to 6 months was 1.20 +/- 1.24 mm and 4.26 +/- 1.59 mm in groups 1 and 2, respectively. Mean CAL gain from baseline to 6 months was 1.63 +/- 1.99 mm and 4.36 +/- 1.92 mm in groups 1 and 2, respectively. In group 2, there was greater decrease in mean IBD (1.41 +/- 0.74 mm or 32.54%) compared to group 1 (0.09 +/- 0.58 mm or 2.16%). CONCLUSION: There was a greater decrease in gingival index and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in patients with chronic periodontitis.
Authors:
Avani R Pradeep; Manojkumar S Thorat
Related Documents :
19300369 - A comparative study of the long term results of root coverage with connective tissue gr...
7601919 - Bacterial resistance following subgingival and systemic administration of minocycline.
9379329 - Results of limited initial periodontal therapy in smokers and non-smokers.
17760539 - Coronally positioned flap for root coverage in smokers and non-smokers: stability of ou...
18166089 - Comparison of injectable calcium phosphate bone cement grafting and open flap debrideme...
11422589 - Evaluation of the effect of tooth vitality on regenerative outcomes in infrabony defects.
17332959 - Robot-assisted laparoscopic surgery of the infrarenal aorta : the early learning curve.
22812499 - Randomized trial of intracardiac echocardiography during cavotricuspid isthmus ablation.
12517299 - Surgical treatment of budd-chiari syndrome induced by behcet's disease.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of periodontology     Volume:  81     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-22     Citation Subset:  D; IM    
Affiliation:
Department of Periodontics, Government Dental College and Research Institute, Karnataka, India. periodontics_gdc@rediffmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Chronic Periodontitis / drug therapy*,  enzymology
Combined Modality Therapy
Delayed-Action Preparations
Female
Gels
Gingiva
Gingival Pocket / drug therapy*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Male
Middle Aged
Periodontal Index
Root Planing*
Simvastatin / administration & dosage*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Gels; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Periodontal diseases, preterm births, and low birth weight: findings from a homogeneous cohort of wo...
Next Document:  Association of periodontitis with rheumatoid arthritis: a pilot study.