Document Detail

Clinical effect of Bretschneider-HTK and St. Thomas cardioplegia on hemodynamic performance after bypass measured using an automatic datalogging database system.
MedLine Citation:
PMID:  3145585     Owner:  NLM     Status:  MEDLINE    
A prospective consecutive study was undertaken to compare the hemodynamic effect of two cardioplegic solutions in CABG patients after bypass, and in relation to aorta occlusion time with the support of a automatic datalogging database. A total of 249 patients were randomized. One group received Bretschneider cardioplegic HTK solution (132 patients, group I) the other group received St. Thomas cardioplegic solution (117 patients, group II). The data was divided in four periods of aortic clamp time: less than or equal to 40 min (group I 26 patients, group II 32 patients); 41-60 min (group I 49 patients, group II 47 patients); 61-80 min (group I 30 patients, group II 29 patients); and greater than 80 minutes (group I 27 pts, group II 9 patients). Anesthesia regime and therapeutic drugs and infusions were given in both groups in similar dosages. Within both groups HR, CO, PAP, PCWP increased after bypass in relation to prebypass values. SVR decreased in both groups by 30%, MAP and PVR decreased only in group I. Between group I and II differences were found in the CI (3.0 vs. 3.3 l/min/m2), MAP (70 vs. 76 mmHg), PMAR (18 vs. 16 mHg), and SVR (827 vs. 954 In significantly more of the patients in group I, sinus rhythm started spontaneously after the release of the aorta clamp (39.5% vs. 20.4%, p less than 0.005). Patients in group I needed temporarily a pacemaker after bypass in 6.3% cases (in 1.1% of patients in group II,). There was no relation of the hemodynamic data in relation to aorta occlusion time within the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
R C Gallandat Huet; G F Karliczek; J N van der Heide; U Brenken; B Mooi; J J van der Broeke; I Jenkins; A F de Geus
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  36     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1989-02-16     Completed Date:  1989-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Dept. of Anesthesia, University Hospital Groningen, Netherlands.
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MeSH Terms
Bicarbonates / administration & dosage
Calcium Chloride / administration & dosage
Clinical Trials as Topic
Coronary Artery Bypass*
Coronary Disease / surgery*
Glucose / administration & dosage
Hemodynamics / drug effects*
Magnesium / administration & dosage
Mannitol / administration & dosage
Potassium Chloride / administration & dosage
Procaine / administration & dosage
Random Allocation
Signal Processing, Computer-Assisted*
Sodium Chloride / administration & dosage
Reg. No./Substance:
0/Bicarbonates; 0/Bretschneider cardioplegic solution; 0/St. Thomas' Hospital cardioplegic solution; 10043-52-4/Calcium Chloride; 50-99-7/Glucose; 59-46-1/Procaine; 69-65-8/Mannitol; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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