Document Detail

Clinical and economic outcomes in patients switched to simvastatin in a community-based family medicine practice.
MedLine Citation:
PMID:  20653799     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The introduction of a generic formulation of simvastatin has created the potential to provide significant low-density lipoprotein cholesterol (LDL-C) reduction in a highly cost-effective manner.
METHODS: This retrospective cohort analysis utilised electronic medical record data from a United States, community-based, independent physician family medicine practice. Patients switched from other statins or statin combinations to simvastatin by the family medicine physicians during routine patient care from January 2002 to October 2008 were identified. Equivalent statin dosing, lipid panel changes and National Cholesterol Education Program--Adult Treatment Panel III (NCEP) LDL-C goal attainment rates were compared preswitch and postswitch. The potential economic impact of simvastatin switching was also evaluated.
RESULTS: A total of 78 patients were identified, and in 76.9% of the switches, an equipotent dose of simvastatin was prescribed. All lipid fractions showed small, non-significant increases, with LDL-C having a 2.2 mg/dl (0.06 mmol/l) increase after switching (p = 0.476). NCEP LDL-C goal attainment rates were 79.5% and 78.2% before and after switching, respectively (p = 1.00). Modelled annual cost savings associated with switching were estimated at $671.99 per patient.
CONCLUSIONS: These results demonstrate that an independent family medicine physician practice can successfully perform statin therapeutic substitution during routine patient care. Equivalent clinical outcomes with regards to changes in lipid fractions and NCEP LDL-C goal attainment were observed in conjunction with the potential for reduced costs for patients.
V J Willey; J A Reinhold; K H Willey; B L Kelly; M J Cziraky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  64     ISSN:  1742-1241     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2011-08-01     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  1235-8     Citation Subset:  IM    
Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA 19104, USA.
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MeSH Terms
Anticholesteremic Agents / economics,  therapeutic use*
Cholesterol, LDL / blood
Cost Savings
Cost-Benefit Analysis
Drug Substitution / economics*
Drugs, Generic / economics,  therapeutic use*
Family Practice / economics
Hydroxymethylglutaryl-CoA Reductase Inhibitors / economics,  therapeutic use*
Hypercholesterolemia / drug therapy*,  economics
Middle Aged
Retrospective Studies
Simvastatin / economics,  therapeutic use*
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Drugs, Generic; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin
Comment In:
Int J Clin Pract. 2011 Dec;65(12):1321-2   [PMID:  22093540 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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