Document Detail


Clinical ease of using doxazosin in BPH patients with and without hypertension.
MedLine Citation:
PMID:  15711605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical studies have demonstrated that doxazosin therapy reduced blood pressure (BP) in patients with benign prostatic hyperplasia (BPH) who were hypertensive at baseline but not in patients who were physiologically or pharmacologically normotensive at baseline. In patients with BPH and uncontrolled hypertension, despite treatment with other antihypertensive drugs, the addition of doxazosin resulted in improved control with significant reductions in BP. The new formulation, doxazosin gastrointestinal therapeutic system (GITS), is initiated at a therapeutic dose, simplifying dose titration. Based on its efficacy and pharmacokinetic and tolerability profiles, doxazosin GITS is an effective and well-tolerated treatment for normotensive and hypertensive patients with BPH.
Authors:
W D Steers; R S Kirby
Related Documents :
10069685 - Long-acting lacidipine versus short-acting nifedipine in the treatment of asymptomatic ...
19516185 - Ambulatory blood pressure monitoring predicts cardiovascular events in treated hyperten...
16313275 - An overview of the pharmacology and clinical efficacy of indapamide sustained release.
17925415 - Long-term effect of continuous positive airway pressure on bp in patients with hyperten...
3799425 - Left ventricular ejection dynamics in hypertrophic cardiomyopathy and aortic stenosis: ...
7896565 - Prognostic value of the cold pressor test for hypertension based on 28-year follow-up.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  8     ISSN:  1365-7852     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-02     Completed Date:  2005-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-7     Citation Subset:  IM    
Affiliation:
University of Virginia Hospital West, Charlottesville, Virginia 22908, USA. wds6t@virginia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Doxazosin / administration & dosage,  therapeutic use*
Humans
Hypertension / drug therapy*
Male
Prostatic Hyperplasia / complications*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 74191-85-8/Doxazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term outcome of detectable PSA levels after radical prostatectomy.
Next Document:  Association between hormonal genetic polymorphisms and early-onset prostate cancer.