Document Detail

Clinical ease of using doxazosin in BPH patients with and without hypertension.
MedLine Citation:
PMID:  15711605     Owner:  NLM     Status:  MEDLINE    
Clinical studies have demonstrated that doxazosin therapy reduced blood pressure (BP) in patients with benign prostatic hyperplasia (BPH) who were hypertensive at baseline but not in patients who were physiologically or pharmacologically normotensive at baseline. In patients with BPH and uncontrolled hypertension, despite treatment with other antihypertensive drugs, the addition of doxazosin resulted in improved control with significant reductions in BP. The new formulation, doxazosin gastrointestinal therapeutic system (GITS), is initiated at a therapeutic dose, simplifying dose titration. Based on its efficacy and pharmacokinetic and tolerability profiles, doxazosin GITS is an effective and well-tolerated treatment for normotensive and hypertensive patients with BPH.
W D Steers; R S Kirby
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  8     ISSN:  1365-7852     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-02     Completed Date:  2005-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-7     Citation Subset:  IM    
University of Virginia Hospital West, Charlottesville, Virginia 22908, USA.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Doxazosin / administration & dosage,  therapeutic use*
Hypertension / drug therapy*
Prostatic Hyperplasia / complications*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 74191-85-8/Doxazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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