Document Detail

Clinical and diagnostic features of delayed hypoxic leukoencephalopathy.
MedLine Citation:
PMID:  19196933     Owner:  NLM     Status:  MEDLINE    
Delayed hypoxic leukoencephalopathy is an underrecognized syndrome of delayed demyelination, which is important to consider when delayed onset of neuropsychiatric symptoms follows a hypoxic event. The authors describe clinical and diagnostic features of three such cases, review the pathophysiology of delayed hypoxic leukoencephalopathy, and discuss features which may help distinguish it from toxic leukoencephalopathy.
David R Shprecher; Kevin M Flanigan; A Gordon Smith; Shawn M Smith; Thomas Schenkenberg; John Steffens
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  20     ISSN:  1545-7222     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
University of Rochester, Department of Neurology, 1351 Mt. Hope Ave, Suite 100, Rochester, NY 14620-3917, USA.
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MeSH Terms
Analgesics, Opioid / poisoning
Benzodiazepines / poisoning
Brain / pathology*
Cocaine / poisoning
Cognition Disorders / etiology,  pathology
Depressive Disorder, Major / pathology,  psychology
Fentanyl / poisoning
Fibromyalgia / drug therapy,  psychology
Gait Disorders, Neurologic / chemically induced,  pathology
Hypoxia, Brain / chemically induced,  diagnosis*,  pathology*
Magnetic Resonance Imaging
Methadone / poisoning
Middle Aged
Motor Neurons / physiology
Narcotic Antagonists / poisoning
Neuropsychological Tests
Psychoses, Substance-Induced / pathology,  psychology
Suicide, Attempted
Reg. No./Substance:
0/Analgesics, Opioid; 0/Narcotic Antagonists; 12794-10-4/Benzodiazepines; 437-38-7/Fentanyl; 50-36-2/Cocaine; 76-99-3/Methadone

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