Document Detail

Clinical diagnosis of Creutzfeldt-Jakob disease: accuracy based on analysis of autopsy-confirmed cases.
MedLine Citation:
PMID:  19056094     Owner:  NLM     Status:  MEDLINE    
A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be established readily in typical cases but not in atypical cases. To investigate the accuracy of clinical diagnosis of CJD, such diagnoses were evaluated retrospectively in autopsy cases. Sixty cases were clinically diagnosed as cases of CJD, of which seven were excluded on the basis of pathologic analysis. These seven misdiagnosed patients showed progressive dementia or disturbed consciousness. Myoclonus and periodic sharp-wave complexes (PSWCs) similar to those of CJD were noted in five and four of the seven patients, respectively. Fifty-six cases were pathologically confirmed as cases of CJD, and three of these were not diagnosed clinically as cases of CJD. Myoclonus was noted in 53 of the 56 pathologically confirmed cases, and PSWCs were noted in 49 cases. According to the difficulties that occur in atypical CJD cases lacking typical clinical findings, the importance of pathologic examination was emphasized. Further information from clinicopathologically investigated cases, particularly atypical cases, will aid in the definitive clinical diagnosis of CJD.
Yasushi Iwasaki; Maya Mimuro; Mari Yoshida; Gen Sobue; Yoshio Hashizume
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Publication Detail:
Type:  Journal Article; Validation Studies     Date:  2008-12-03
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  277     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Department of Neurology, Oyamada Memorial Spa Hospital, 5538-1 Yamada-cho, Yokkaichi 512-1111, Japan.
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MeSH Terms
Aged, 80 and over
Creutzfeldt-Jakob Syndrome / diagnosis*
Dementia / diagnosis*
Diagnosis, Differential
Magnetic Resonance Imaging / standards*
Middle Aged
Myoclonus / diagnosis*
Retrospective Studies

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