Document Detail

Clinical course and outcome of heart transplant recipients: single center experience at the National Cardiovascular Center in Japan.
MedLine Citation:
PMID:  20716844     Owner:  NLM     Status:  MEDLINE    
The number of heart transplant (HTx) surgeries in Japan is expected to increase under the Revised Organ Transplant Law. To date, among 69 HTx surgeries performed in Japan, 27 operations (39.1%) were performed at our institution, the National Cardiovascular Center (NCVC), located in Osaka. We have reviewed the outcomes of HTx conducted at NCVC during a 10 year period (May 1999 to January 2009). Among 27 heart transplant recipients at NCVC, the clinical charts of 26 recipients whose post-HTx period exceeded 1 year were retrospectively reviewed and compared to data from the International Society for Heart and Lung Transplantation (ISHLT) Registry. The survival rate of our recipients was 96.2% at 10.8 years, which was excellent even compared to the ISHLT Registry. The immunosuppressive regimen at NCVC was equivalent to that of the ISHLT Registry, except for more frequent use of Muromonab-CD3 (26.9% versus 3.3%, P < 0.0001) and an initial CSA-based regimen (65.3% versus 34.4%, P < 0.001). The drug we use for induction therapy has been recently changed from Muromonab-CD3 to Basiliximab. The incidences of post-HTx hypertension, diabetes, hyperlipidemia, and renal insufficiency were significantly less in patients at NCVC compared to those in the ISHLT Registry, however, the incidence of transplant coronary artery disease (TxCAD) was almost identical. Clinical review of post-HTx outcome at NCVC can provide useful information for Japanese transplant cardiologists who will engage in HTx management.
Noboru Oda; Tomoko S Kato; Kazuo Komamura; Akihisa Hanatani; Akiko Mano; Kazuhiko Hashimura; Masanori Asakura; Kazuo Niwaya; Toshihiro Funatsu; Junjiro Kobayashi; Kyoichi Wada; Shuji Hashimoto; Hatsue Ishibashi-Ueda; Yukiko Nakano; Yasuki Kihara; Masafumi Kitakaze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  264-71     Citation Subset:  IM    
Department of Cardiovascular Medicine, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Cohort Studies
Graft Rejection / epidemiology,  prevention & control
Heart Diseases / complications,  epidemiology*,  surgery*
Heart Transplantation*
Middle Aged
Retrospective Studies
Survival Rate
Treatment Outcome
Young Adult

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