| Clinical course of collagenous colitis over a period of 10 years. | |
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MedLine Citation:
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PMID: 16981069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to evaluate the long-term outcome of patients with collagenous colitis 10 years after the diagnosis. PATIENTS AND METHODS: In 1989/1990, 65 patients were diagnosed to have collagenous colitis. Initially and after an interval of ten years these patients were asked to complete a questionnaire including onset and duration of diarrhea, stool frequency and consistency, other gastrointestinal symptoms including weight loss, drug history, treatment response and concomitant diseases. RESULTS: Questionnaires from 47 patients (72.3 %) (female 40; mean age 68 years, range 41 - 95 years) were available for analysis. After a follow-up of ten years, 11 patients (23.4 %) had persistent diarrhea with no change of frequency and consistency compared to baseline. Four patients (8.5 %) showed a reduction of diarrhea frequency of at least 50 %. Diarrhea was resolved in 23 patients (48.9 %) during the follow-up period. Of those, 20 patients received anti-inflammatory treatment. After a complete resolution of diarrhea during the long-term follow-up, 9 patients (19.2 %) showed recurrence of diarrheal symptoms. None of the patients developed any malignancies of the GI-tract. CONCLUSION: The long-term outcome of CC is benign with a resolution of diarrhea in up to 50 % of patients receiving anti-inflammatory treatment. About 30 % of patients may experience persistent diarrhea even 10 years after diagnosis. Our data confirm that CC is a chronic disorder with a variable course of symptoms during a long-term follow-up. |
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Authors:
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A Madisch; S Miehlke; M Lindner; B Bethke; M Stolte |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Zeitschrift für Gastroenterologie Volume: 44 ISSN: 0044-2771 ISO Abbreviation: Z Gastroenterol Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-11-28 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0033370 Medline TA: Z Gastroenterol Country: Germany |
Other Details:
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Languages: eng Pagination: 971-4 Citation Subset: IM |
Affiliation:
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Medical Department I, University Hospital Dresden. ahmed.madisch@uniklinikum-dresden.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anti-Inflammatory Agents / therapeutic use* Colitis, Collagenous / complications, diagnosis, drug therapy* Diarrhea / diagnosis, etiology, prevention & control* Female Humans Longitudinal Studies Male Middle Aged Prognosis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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