Document Detail

Clinical course of collagenous colitis over a period of 10 years.
MedLine Citation:
PMID:  16981069     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to evaluate the long-term outcome of patients with collagenous colitis 10 years after the diagnosis. PATIENTS AND METHODS: In 1989/1990, 65 patients were diagnosed to have collagenous colitis. Initially and after an interval of ten years these patients were asked to complete a questionnaire including onset and duration of diarrhea, stool frequency and consistency, other gastrointestinal symptoms including weight loss, drug history, treatment response and concomitant diseases. RESULTS: Questionnaires from 47 patients (72.3 %) (female 40; mean age 68 years, range 41 - 95 years) were available for analysis. After a follow-up of ten years, 11 patients (23.4 %) had persistent diarrhea with no change of frequency and consistency compared to baseline. Four patients (8.5 %) showed a reduction of diarrhea frequency of at least 50 %. Diarrhea was resolved in 23 patients (48.9 %) during the follow-up period. Of those, 20 patients received anti-inflammatory treatment. After a complete resolution of diarrhea during the long-term follow-up, 9 patients (19.2 %) showed recurrence of diarrheal symptoms. None of the patients developed any malignancies of the GI-tract. CONCLUSION: The long-term outcome of CC is benign with a resolution of diarrhea in up to 50 % of patients receiving anti-inflammatory treatment. About 30 % of patients may experience persistent diarrhea even 10 years after diagnosis. Our data confirm that CC is a chronic disorder with a variable course of symptoms during a long-term follow-up.
A Madisch; S Miehlke; M Lindner; B Bethke; M Stolte
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Zeitschrift für Gastroenterologie     Volume:  44     ISSN:  0044-2771     ISO Abbreviation:  Z Gastroenterol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-11-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  971-4     Citation Subset:  IM    
Medical Department I, University Hospital Dresden.
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents / therapeutic use*
Colitis, Collagenous / complications,  diagnosis,  drug therapy*
Diarrhea / diagnosis,  etiology,  prevention & control*
Longitudinal Studies
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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