| Clinical correlation between increased lung to heart ratio of technetium-99m sestamibi and multivessel coronary artery disease. | |
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MedLine Citation:
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PMID: 15882667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An increased lung to heart ratio (LHR) on thallium-201 (Tl-201) stress myocardial perfusion imaging (MPI) is a predictor of adverse cardiac events and identifies people with extensive coronary artery disease (CAD). The implications of increased LHR in patients undergoing stress technetium-99m (tc-99m) sestamibi are developing. Our aim is to evaluate the relationship between increased LHR and extent of CAD in patients undergoing tc-99m sestamibi MPI. METHODS: We reviewed the records and images of 530 consecutive subjects who underwent exercise or adenosine tc-99 m sestamibi MPI. One hundred thirty-two had transient or partially reversible myocardial perfusion defects and 79 (exercise=34, adenosine=45, male=43, female=36, mean age=61 years) of these underwent coronary angiography (study population). The average LHR of these 79 subjects was compared to 79 patients (control population) with normal scans (exercise=50, adenosine=29, male=34, female=45, mean age=60 years). RESULTS: The mean LHR (+/-SE) in subjects with normal scans was 0.30+/-0.01. The mean LHR for those with abnormal scans and single vessel CAD who underwent exercise was 0.32+/-0.01 and pharmacological stress was 0.31+/-0.01. There was no statistically significant difference between the LHR of those with a normal scan and those with single vessel disease and an abnormal scan. However, there was a statistically significant association between the elevated LHR and multi-vessel CAD. The mean LHR for subjects with multi-vessel CAD with exercise was 0.39+/-0.01 (p=0.000) and for adenosine was 0.39+/-0.02 (p=0.000). CONCLUSION: An elevated LHR in patients undergoing exercise or pharmacological tc-99m MPI correlates with multi-vessel CAD. |
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Authors:
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Shekar P Kumar; Stacy D Brewington; Kevin F O'Brien; Assad Movahed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 101 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-10 Completed Date: 2005-09-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 219-22 Citation Subset: IM |
Affiliation:
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Section of Cardiology, Department of Internal Medicine, PCMH Teaching annex #378, East Carolina University Brody School of Medicine, Greenville, NC 27858-4354, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use Coronary Artery Disease / metabolism*, physiopathology, radionuclide imaging Coronary Circulation / physiology Exercise Test Female Humans Lung / metabolism* Male Middle Aged Myocardium / metabolism* Radiopharmaceuticals / pharmacokinetics* Retrospective Studies Severity of Illness Index Technetium Tc 99m Sestamibi / pharmacokinetics* Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Vasodilator Agents; 109581-73-9/Technetium Tc 99m Sestamibi; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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