Document Detail

Clinical correlates of very high brain natriuretic peptide levels in hospitalized patients.
MedLine Citation:
PMID:  18256556     Owner:  NLM     Status:  MEDLINE    
While low brain natriuretic peptide (BNP) values have been shown to improve diagnostic accuracy by excluding congestive heart failure in acute dyspnea, the meaning of excessively elevated BNP is not clear. This is a retrospective analysis of clinical, echocardiographic, and laboratory data in patients with BNP values >2500 ng/L. Sixty-seven patients (36 men) with a median age of 79 years were included. The median BNP level was 3118 ng/L (2506-5000 ng/L). Forty-six percent of the patients had no dyspnea or New York Heart Association class II dyspnea. Most patients had impaired renal function. BNP value did not correlate with ejection fraction (r=0.2; P=.15) and weakly correlated with left ventricular end-diastolic diameter index (r=0.26; P=.02). Very high BNP values only poorly correlated with dyspnea and traditional echocardiographic markers of congestive heart failure. The clinical usefulness of very high BNP values is questionable and needs evaluation in a prospective trial.
Florim Cuculi; Brigitte Walz; Michel Zuber; Markus Roos; Paul Erne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American heart hospital journal     Volume:  6     ISSN:  1541-9215     ISO Abbreviation:  Am Heart Hosp J     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156064     Medline TA:  Am Heart Hosp J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Department of Cardiology Kantonsspital Luzern, Luzern, Switzerland.
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MeSH Terms
Aged, 80 and over
Cardiac Output, Low / diagnosis,  etiology
Echocardiography, Doppler
Kidney Failure / diagnosis
Middle Aged
Natriuretic Peptide, Brain / analysis*,  diagnostic use
Retrospective Studies
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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