Document Detail


Clinical correlates of quantitative EEG alterations in alcoholic patients.
MedLine Citation:
PMID:  16495144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the incidence and clinical correlations of abnormal QEEG features in alcoholic patients. METHODS: Quantitative EEG (frequency analysis, absolute and relative powers of the four classical bands) was assessed in 191 male alcoholic patients admitted in our facility for detoxification process. All underwent psychiatric, medical and neurological examination prior to the EEG recording, in search for specific clinical or paraclinical findings. The presence or absence of relevant clinical features was codified as nominal dichotomic variables to be related to specific QEEG features. RESULTS: Only 7 patients had normal QEEG. The most frequent alteration (81 cases) was decreased power in slow (delta and theta) bands with a concurrent increase in beta band, followed by decreased power only in slow bands (33), increase only in beta band (29), decrease in both slow and alpha bands without beta alterations (28), decrease only in alpha band (6) and others. Alterations in slow and beta bands were uncorrelated. However, a significant correlation was found between decreased power in slow bands and cortical atrophy as revealed by MRI (especially in patients with early onset of alcoholism), time elapsed from the beginning of alcoholic habits (but only in younger or early onset subjects) and in a lesser degree arterial hypertension, but neither with age nor any other clinical or psychiatric feature. On the other hand, increased power in beta band correlated mainly with the use of benzodiazepines, sensoperceptual alterations (hallucinations, illusions), clinical seizures and family history of alcoholism. The effects of those variables were strongly interrelated. CONCLUSIONS: Decreased power in slow bands in alcoholic patients may be an indicator of brain atrophy or chronic brain damage, while increase in beta band is related to medication use, family history of alcoholism, hallucinations and seizures, suggesting a state of cortical hyperexcitability. SIGNIFICANCE: This study show the relation of specific QEEG alterations to certain clinical features found in alcoholics, in a further attempt to elucidate the semiological value of those alterations in individual patients.
Authors:
Pedro Coutin-Churchman; Rocío Moreno; Yelitza Añez; Fátima Vergara
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Publication Detail:
Type:  Journal Article     Date:  2006-02-21
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  117     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-06-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  740-51     Citation Subset:  IM    
Affiliation:
Hospital Psiquiátrico San Juan de Dios, Urb. Campo Claro. Los Curos, Edo. Mérida 5101, Venezuela. coutinpe@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Alcohol Withdrawal Seizures / physiopathology
Alcohol-Induced Disorders, Nervous System / diagnosis*,  physiopathology
Alcoholism / complications*
Atrophy / chemically induced,  diagnosis,  physiopathology
Benzodiazepines / adverse effects
Brain Damage, Chronic / chemically induced,  diagnosis,  physiopathology
Central Nervous System Depressants / adverse effects
Cerebral Cortex / drug effects*,  physiopathology
Drug Interactions / physiology
Electroencephalography / methods*
Ethanol / adverse effects*
Genetic Predisposition to Disease / genetics
Glutamic Acid / metabolism
Hallucinations / chemically induced,  physiopathology
Humans
Male
Middle Aged
Models, Neurological
Nerve Degeneration / chemically induced,  genetics,  metabolism
Neurotoxins / metabolism
gamma-Aminobutyric Acid / metabolism
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Neurotoxins; 12794-10-4/Benzodiazepines; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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