Document Detail


Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study.
MedLine Citation:
PMID:  22727409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Red blood cell (RBC) levels of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA, the omega-3 index, expressed as a percent of total fatty acids) are inversely related to risk for cardiovascular disease (CVD). Although several mechanisms underlying this relationship have been proposed, understanding the associations between the omega-3 index and markers of CVD in the community can shed additional light on this question. The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index.
METHODS: RBC samples (n = 3196) drawn between 2005 and 2008 from participants in the Framingham Study [Examination 8 of the Offspring cohort plus Examination 3 of the Omni (minorities) cohort] were analyzed for fatty acid composition by gas chromatography.
RESULTS: The mean (SD) omega-3 index was 5.6% (1.7%). In multivariable regression models, the factors significantly and directly associated with the omega-3 index were age, female sex, higher education, fish oil supplementation, dietary intake of EPA + DHA, aspirin use, lipid pharmacotherapy, and LDL-cholesterol. Factors inversely associated were Offspring cohort, heart rate, waist girth, triglycerides and smoking. The total explained variability in the omega-3 index for the fully adjusted model was 73%, which included major components due to heritability (24%), EPA + DHA intake (25%), and fish oil supplementation (15%).
CONCLUSION: The variability in the omega-3 index is determined primarily by dietary and genetic factors. An increased omega-3 index is associated with a generally cardioprotective risk factor milieu.
Authors:
William S Harris; James V Pottala; Sean M Lacey; Ramachandran S Vasan; Martin G Larson; Sander J Robins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-07
Journal Detail:
Title:  Atherosclerosis     Volume:  225     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-02     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  425-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / blood*,  epidemiology,  genetics*,  prevention & control
Chi-Square Distribution
Chromatography, Gas
Dietary Supplements
Docosahexaenoic Acids / blood*,  therapeutic use
Eicosapentaenoic Acid / blood*,  therapeutic use
Erythrocytes / metabolism*
Female
Genetic Predisposition to Disease
Heredity
Humans
Least-Squares Analysis
Linear Models
Lipid Metabolism / genetics*
Male
Massachusetts / epidemiology
Middle Aged
Multivariate Analysis
Phenotype
Risk Assessment
Risk Factors
Time Factors
Grant Support
ID/Acronym/Agency:
N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 HL089590/HL/NHLBI NIH HHS; R01 HL089590/HL/NHLBI NIH HHS; T32 GM074905/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid
Comments/Corrections

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