Document Detail


Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study.
MedLine Citation:
PMID:  19808499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Electrocardiographic QT interval prolongation is a risk factor for sudden cardiac death and drug-induced arrhythmia. The clinical correlates and heritability of QT interval duration in blacks have not been well studied despite their higher risk for sudden cardiac death compared with non-Hispanic whites. We sought to investigate potential correlates of the QT interval and estimate its heritability in the Jackson Heart Study.
METHODS AND RESULTS: The Jackson Heart Study comprises a sample of blacks residing in Jackson, Miss, of whom 5302 individuals with data at the baseline examination were available for study. Jackson Heart Study participants on QT-altering medications, with bundle-branch block, paced rhythm, atrial fibrillation/flutter, or other arrhythmias were excluded, resulting in a sample of 4660 individuals eligible for analyses. The relation between QT and potential covariates was tested using multivariable stepwise linear regression. Heritability was estimated using Sequential Oligogenic Linkage Analysis Routine in a subset of 1297 Jackson Heart Study participants in 292 families; the remaining sample included unrelated individuals. In stepwise multivariable linear regression analysis, covariates significantly associated with QT interval duration included R-R interval, sex, QRS duration, age, serum potassium, hypertension, body mass index, coronary heart disease, diuretic use, and Sokolow-Lyon voltage (P < or = 0.01 for all). The heritability of QT interval duration in the age-, sex-, and R-R interval-adjusted model and in the fully adjusted model was 0.41 (SE, 0.07) and 0.40 (SE, 0.07; P < 10(-11) for both), respectively.
CONCLUSIONS: There is substantial heritability of adjusted QT interval in blacks, supporting the need for further investigation to identify its genetic determinants.
Authors:
Ermeg L Akylbekova; Richard S Crow; William D Johnson; Sarah G Buxbaum; Stephanie Njemanze; Ervin Fox; Daniel F Sarpong; Herman A Taylor; Christopher Newton-Cheh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-27
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  2     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-10-29     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*,  statistics & numerical data*
Aged
Aged, 80 and over
Death, Sudden, Cardiac / ethnology*
Female
Genetic Predisposition to Disease / ethnology
Heart Failure / ethnology
Humans
Linear Models
Long QT Syndrome / ethnology*,  genetics*
Male
Middle Aged
Mississippi / epidemiology
Multivariate Analysis
Prevalence
Risk Factors
Grant Support
ID/Acronym/Agency:
K23 HL080025/HL/NHLBI NIH HHS; K23 HL080025/HL/NHLBI NIH HHS; K23 HL080025-05/HL/NHLBI NIH HHS; N01-HC-95170/HC/NHLBI NIH HHS; N01-HC-95171/HC/NHLBI NIH HHS; N01-HC-95172/HC/NHLBI NIH HHS
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