Document Detail

Clinical comparison of three different anaesthetic depth monitors during cardiopulmonary bypass.
MedLine Citation:
PMID:  15644019     Owner:  NLM     Status:  MEDLINE    
The lack of a gold standard complicates the evaluation and comparison of anaesthetic depth monitors. This randomised study compares three different depth-of-anaesthesia monitors during cardiopulmonary bypass (CPB) at 34 degrees C with fentanyl/propofol anaesthesia adjusted clinically and blinded to the monitors. Coronary artery bypass grafting patients (n = 21) were randomly assigned to all three possible paired combinations of three monitors: Bispectral Index (Aspect Medical), AAI auditory evoked potential (Danmeter), Entropy (Datex-Ohmeda). Indices were manually recorded every 5 min during CPB. Agreement between paired indices was classified as good, non-, or disagreement. Anaesthesia was classed as adequate, inadequate, or excessive according to recommended index values. Of the 255 paired indices recorded, 62% showed good agreement, 33% showed non-agreement, and 5% showed disagreement. Using good agreement between two monitors as a gold standard, a quarter of the measurements indicate inappropriate anaesthetic depth monitoring during CPB with clinically titrated anaesthetic depth.
C Tirén; R E Anderson; G Barr; A Owall; J G Jakobsson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-12     Completed Date:  2005-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  AIM; IM    
Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Sweden.
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MeSH Terms
Aged, 80 and over
Anesthetics, Combined / pharmacology
Anesthetics, General / pharmacology*
Cardiopulmonary Bypass*
Consciousness / drug effects*
Electroencephalography / drug effects
Evoked Potentials, Auditory / drug effects
Middle Aged
Monitoring, Intraoperative / methods*
Reproducibility of Results
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, General

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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