Document Detail


Clinical comparison of fenoterol and albuterol administered by inhalation. A double-blind study.
MedLine Citation:
PMID:  344007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of inhaling 0.4 mg of fenoterol hydrobromide (Berotec), 0.2 mg of albuterol (salbutamol), or placebo were compared in a double-blind three-way crossover study in a group of 12 asthmatic patients. After inhalation of fenoterol, the maximum increase in the forced expiratory volume in the first second (FEV1) was 0.76 L (48 percent) and in the peak expiratory flow (PEF) was 100 L/min (47 percent). The corresponding figures after inhalation of albuterol were 0.68 L (46 percent) and 98 L/min (48 percent), respectively. In comparison with administration of placebo, the FEV1 was significantly increased until six hours after inhalation of either drug. From three to six hours after inhalation, the effect of administration of fenoterol (as measured by FEV1 or PEF) significantly exceeded that of albuterol. Administration of either drug resulted in approximately equal bronchodilation (as measured by the increase in FEV1 or PEF), the effect of inhalation of fenoterol being of longer duration.
Authors:
E Huhti; A Poukkula
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Chest     Volume:  73     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  348-51     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Albuterol / adverse effects,  therapeutic use*
Asthma / drug therapy*
Clinical Trials as Topic
Double-Blind Method
Drug Evaluation
Ethanolamines / therapeutic use*
Female
Fenoterol / adverse effects,  therapeutic use*
Forced Expiratory Volume
Heart Rate / drug effects
Humans
Male
Middle Aged
Peak Expiratory Flow Rate
Placebos
Vital Capacity
Chemical
Reg. No./Substance:
0/Ethanolamines; 0/Placebos; 13392-18-2/Fenoterol; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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