| Clinical comparison of fenoterol and albuterol administered by inhalation. A double-blind study. | |
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MedLine Citation:
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PMID: 344007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of inhaling 0.4 mg of fenoterol hydrobromide (Berotec), 0.2 mg of albuterol (salbutamol), or placebo were compared in a double-blind three-way crossover study in a group of 12 asthmatic patients. After inhalation of fenoterol, the maximum increase in the forced expiratory volume in the first second (FEV1) was 0.76 L (48 percent) and in the peak expiratory flow (PEF) was 100 L/min (47 percent). The corresponding figures after inhalation of albuterol were 0.68 L (46 percent) and 98 L/min (48 percent), respectively. In comparison with administration of placebo, the FEV1 was significantly increased until six hours after inhalation of either drug. From three to six hours after inhalation, the effect of administration of fenoterol (as measured by FEV1 or PEF) significantly exceeded that of albuterol. Administration of either drug resulted in approximately equal bronchodilation (as measured by the increase in FEV1 or PEF), the effect of inhalation of fenoterol being of longer duration. |
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Authors:
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E Huhti; A Poukkula |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Chest Volume: 73 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-05-17 Completed Date: 1978-05-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 348-51 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Albuterol / adverse effects, therapeutic use* Asthma / drug therapy* Clinical Trials as Topic Double-Blind Method Drug Evaluation Ethanolamines / therapeutic use* Female Fenoterol / adverse effects, therapeutic use* Forced Expiratory Volume Heart Rate / drug effects Humans Male Middle Aged Peak Expiratory Flow Rate Placebos Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Ethanolamines; 0/Placebos; 13392-18-2/Fenoterol; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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