Document Detail

Clinical classification of bioengineered skin use and its correlation with healing of diabetic and venous ulcers.
MedLine Citation:
PMID:  15274699     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic wounds are being treated with bioengineering skin constructs. Yet, there is no standard way of assessing these wounds. We developed a classification system to evaluate wounds after construct application. The classification system evaluates the early clinical effect of bioengineered skin and early construct appearance giving a total score named the skin substitute score. OBJECTIVE: Apply classification system to both venous and diabetic foot ulcers and determine whether classification system has validity and predictability for healing. METHODS: Evaluated serial photographs in 83 and 78 patients with diabetic foot ulcers and in 84 and 83 patients with venous ulcer on Days 7 and 14, respectively, treated with a bilayered bioengineered skin construct. Applied the classification system and determined the percentages of healed patients. RESULTS: There was a significant correlation between better skin substitute score and complete wound closure for both venous ulcers p=0.002 on Day 7 and p=0.01 on Day 14) and diabetic foot ulcers p=0.0005 on Day 7 and p<0.0001 on Day 14). CONCLUSION: Optimal clinical effect was associated with complete wound closure. As the clinical effect becomes less than optimal continued clinical persistence of the construct becomes important. This classification system seems to have validity in predicting complete wound closure in wounds treated with a bilayered bioengineered skin construct.
Liliana J Saap; Kevin Donohue; Vincent Falanga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Validation Studies    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  30     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2004-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-100     Citation Subset:  IM    
Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, Rhode Island 02908, USA.
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MeSH Terms
Aged, 80 and over
Diabetic Foot / pathology,  surgery*
Leg Ulcer / pathology,  surgery*
Middle Aged
Prospective Studies
Randomized Controlled Trials as Topic
Severity of Illness Index*
Skin, Artificial*
Wound Healing
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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