Document Detail

Clinical and chemical properties of a novel mucosal bioadhesive agent.
MedLine Citation:
PMID:  3150444     Owner:  NLM     Status:  MEDLINE    
Through clinical observations and known chemical properties, this series of studies delineates properties of a new bioadhesive agent available commercially (Zilactin). Using a previously published protocol, we determined that the duration of the film formed on mucosa was not altered after exposure to extremes in temperatures encountered in drinking hot and cold liquids. In addition, through dissection of the agent into several component parts, we were able to determine a specific role for each of the acidic ingredients. It is clear that the solubility of hydroxypropyl cellulose (Klucel) is altered by esterification of the polymer by tannic and salicylic acids and that boric acid effectively crosslinks these to form Zilactin's characteristic clinical film. Other fine points of the chemical reactions are detailed. These studies are intended to serve as a foundation for the future manipulation and application of this agent in oral mucosal diseases.
B Rodu; C M Russell; A J Desmarais
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology     Volume:  17     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-07-10     Completed Date:  1989-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  564-7     Citation Subset:  D; IM    
Department of Diagnostic Sciences, University of Alabama School of Dentistry, Wilmington.
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MeSH Terms
Biocompatible Materials*
Boric Acids
Cellulose / analogs & derivatives*
Chemistry, Physical
Hydrolyzable Tannins
Materials Testing
Mouth Mucosa
Physicochemical Phenomena
Salicylic Acids
Time Factors
Reg. No./Substance:
0/Adhesives; 0/Biocompatible Materials; 0/Boric Acids; 0/Hydrolyzable Tannins; 0/Salicylic Acids; 0/Vehicles; 11113-50-1/boric acid; 9004-34-6/Cellulose; 9004-64-2/hydroxypropylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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