| Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma. | |
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MedLine Citation:
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PMID: 20733268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sunitinib is a multi-targeted tyrosine kinase inhibitor that is effective for advanced renal cell carcinoma. However, sunitinib often causes hypothyroidism. In this study, we report eight cases with thyroid dysfunction that occurred during sunitinib treatment for advanced renal cell carcinoma. In seven cases, mild hypothyroidism developed early in the first treatment cycle, and recovered spontaneously. Transient hyperthyroidism was observed during the second or third treatment cycles and was preceded by a rapid increase in thyroglobulin levels. (99m)Tc scintigraphy in the hyperthyroid state showed decreased thyroidal uptake of (99m)TcO(4)(-), suggesting destructive thyroiditis. Hypothyroidism subsequently developed, requiring levothyroxine replacement therapy. Ultrasonography showed a hypoechogenic pattern of the parenchyma and decreased intrathyroidal blood flow. The thyroid glands ultimately became atrophic, which may progress to permanent hypothyroidism. These findings suggest that sunitinib-induced hypothyroidism may occur frequently and may be a consequence of thyroiditis with transient thyrotoxicosis. The marked decrease in thyroid size due to reduced capillary blood flow induced by VEGF receptor inhibition may cause delayed and/or permanent hypothyroidism. Therefore, thyroid function should be monitored in all patients treated with sunitinib. |
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Authors:
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Shuichi Sato; Kazuhisa Muraishi; Junichi Tani; Yuko Sasaki; Ichiro Tokubuchi; Yuji Tajiri; Kentaro Yamada; Shigetaka Suekane; Jiro Miyajima; Kei Matsuoka; Yuji Hiromatsu |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-08-21 |
Journal Detail:
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Title: Endocrine journal Volume: 57 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2011-03-03 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 873-80 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan. dem_sato@med.kurume-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / adverse effects*, therapeutic use Atrophy Carcinoma, Renal Cell / drug therapy* Disease Progression Female Humans Hyperthyroidism / chemically induced, pathology, physiopathology Hypothyroidism / chemically induced*, pathology Indoles / adverse effects*, therapeutic use Japan Male Middle Aged Organ Size / drug effects Protein Kinase Inhibitors / adverse effects, therapeutic use Pyrroles / adverse effects*, therapeutic use Regional Blood Flow / drug effects Thyroid Gland / blood supply, drug effects*, pathology Thyroiditis / chemically induced Thyrotoxicosis / chemically induced, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Indoles; 0/Protein Kinase Inhibitors; 0/Pyrroles; 0/sunitinib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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