| Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere). | |
| | |
MedLine Citation:
|
PMID: 9093729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Docetaxel, a semi-synthetic taxane may cause a usually mild sensory neuropathy. We describe the clinical characteristics of five patients who developed a more severe neuropathy following treatment with docetaxel. PATIENTS AND METHODS: All patients were treated in phase II studies with 100 mg/m2 docetaxel in three weekly cycles, without steroid administration. RESULTS: The clinical picture in these patients was dominated by a sensory neuropathy, but in one case severe weakness was present. Another patient developed Lhermitte's sign. Signs and symptoms are usually reversible after discontinuation of docetaxel administration, but in three patients symptoms worsened for some time after the end of treatment before improvement occurred. CONCLUSION: Severe docetaxel neuropathy may especially occur following treatment with cumulative dosage over 600 mg/m2; in patients treated with this dosage a moderate or severe neuropathy may not be rare. |
| | |
Authors:
|
P H Hilkens; J Verweij; C J Vecht; G Stoter; M J van den Bent |
Related Documents
:
|
8232929 - Presentation and initial clinical course in patients with chronic inflammatory demyelin... 6089719 - Acute dysautonomia and polyneuropathy. 7180419 - Late sequelae of iatrogenic damage to chorda tympani nerve. 2311939 - Cutaneous eruption with or without ocular complications in patients with herpes zoster ... 616609 - The carpal tunnel syndrome: a clinical and electrophysiological study of 250 patients. 16787509 - Small-fibre neuropathy in female fabry patients: reduced allodynia and skin blood flow ... 9444579 - Efficacy of conservative treatment of lumbar disc herniation. 17525889 - Therapy for polycythemia vera and essential thrombocythemia is driven by the cardiovasc... 20020409 - Comparison of fluid status in patients treated by different modalities of peritoneal di... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 8 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 1997 Feb |
Date Detail:
|
Created Date: 1997-06-05 Completed Date: 1997-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 187-90 Citation Subset: IM |
Affiliation:
|
Department of Neuro-Oncology, Rotterdam Cancer Institute, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antineoplastic Agents, Phytogenic / adverse effects* Female Humans Male Middle Aged Paclitaxel / adverse effects, analogs & derivatives* Peripheral Nervous System Diseases / chemically induced* Taxoids* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Taxoids; 114977-28-5/docetaxel; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of the 5-HT3 antagonists ondansetron and dolasetron in the control of delayed onset nausea ...
Next Document: Ifosfamide and paclitaxel salvage chemotherapy for advanced epithelial ovarian cancer.