Document Detail

Clinical characteristics of prognostic factors in poorly differentiated (G3) endometrioid adenocarcinoma in Japan.
MedLine Citation:
PMID:  15681600     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been reported that prognosis is less favorable in poorly (G3) differentiated endometrioid adenocarcinoma than in well (G1) or moderately (G2) differentiated endometrioid adenocarcinoma. The goal of this study is therefore to analyze the prognosis of G3 endometrioid adenocarcinoma and various factors that may predict a favorable prognosis. METHOD: This study included 699 Japanese cases of endometrioid adenocarcinoma at the International Federation of Gynaecology and Obstetrics (FIGO) surgical stages I-IV (including 74 G3 cases). We investigated the G1-G3 survival rates of endometrioid adenocarcinoma cases and the G2 and G3 disease-free periods. We also examined the clinicopathological characteristics of G3 endometrioid adenocarcinoma. RESULT: The prognosis was poor in stages III and IV in G3 and in G2 cases, but recurrence was observed more frequently in G3 cases than in G2 cases. Adnexal metastasis and high pre-surgery CA602 values showed significantly low P-values for survival. CONCLUSIONS: We suggest that the risk of late recurrence is higher in G3 than in G2 cases. The absence of adnexal metastasis and low pre-surgery CA19-9 values may suggest a relatively favorable prognosis in G3 endometrioid adenocarcinoma.
Yoshiko Kuwabara; Nobuyuki Susumu; Kouji Banno; Takeshi Hirao; Makiko Kawaguchi; Wataru Yamagami; Nao Suzuki; Daisuke Aoki; Shiro Nozawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  35     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-03-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Adenosquamous / mortality,  pathology
Carcinoma, Endometrioid / mortality,  pathology*,  secondary
Cell Cycle
Disease-Free Survival
Endometrial Neoplasms / mortality,  pathology*
Lymph Nodes / pathology*
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Ovarian Neoplasms / secondary
Survival Rate
Uterine Cervical Neoplasms / pathology

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