| Clinical characteristics and outcomes of empyema thoracis in 117 patients: a comparative analysis of tuberculous vs. non-tuberculous aetiologies. | |
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MedLine Citation:
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PMID: 17045789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Empyema thoracis remains a major problem in developing countries. Clinical outcomes in tuberculous empyema are generally believed to be worse than in non-tuberculous aetiologies because of the presence of concomitant fibrocavitary parenchymal disease, frequent bronchopleural fistulae and poor general condition of patients. We performed a prospective study over a 2-year period with the objective of comparing the clinical characteristics and outcomes of patients with tuberculous vs. non-tuberculous empyema. METHODS: Prospective study of all cases of non-surgical thoracic empyema seen at a tertiary care centre in North India over a 2-year period. A comparative analysis of clinical characteristics, treatment modalities and outcomes of patients with tuberculous vs. non-tuberculous empyema was carried out. Factors associated with poor outcomes were analysed using multivariate logistic regression. RESULTS: One hundred and seventeen cases of empyema were seen in the study period of which 95 had non-tuberculous and 41 had tuberculous empyema. Malnutrition and bronchopleural fistulae (BPF) were more common and duration of symptoms longer in the tuberculous empyema group. Time to resolution of fever, duration of pleural drainage and pleural thickening >2 cm were significantly greater as well. Eight (10.5%) patients with non-tuberculous empyema and four (9.8%) with tuberculous empyema succumbed. Presence of a BPF was significantly associated with poor outcomes on multivariate logistic regression analysis. CONCLUSIONS: Tuberculous empyema remains a common cause of thoracic empyema in India though it ranked second amongst all causes of empyema after community acquired lung infections in this study. Tuberculous empyema is associated with longer duration of symptoms, greater duration of pleural drainage and more residual pleural fibrosis. |
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Authors:
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P Malhotra; A N Aggarwal; R Agarwal; P Ray; D Gupta; S K Jindal |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-10-12 |
Journal Detail:
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Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-09 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 423-30 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. dranshupuneet@yahoo.co.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Infective Agents / therapeutic use Bronchial Fistula / complications, epidemiology Drainage Empyema, Pleural / drug therapy, epidemiology*, etiology Empyema, Tuberculous / drug therapy, epidemiology, etiology Female Fistula / complications, epidemiology Humans India / epidemiology Male Middle Aged Nutrition Disorders / complications, epidemiology Pleura / pathology Pleural Diseases / complications, epidemiology Pleural Effusion / microbiology Prospective Studies Respiratory Tract Infections / complications, drug therapy, epidemiology Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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