Document Detail

Clinical characteristics of oral tolerance induction of IgE-mediated and non-IgE-mediated food allergy using interferon gamma.
MedLine Citation:
PMID:  20819314     Owner:  NLM     Status:  MEDLINE    
Food allergies are classified as IgE-mediated food allergies (IFAs) and non-IgE-mediated food allergies (NFAs). Recently, oral immunotherapy (OIT) has been found to be successful for treating both IFA and NFA, especially using interferon (IFN) gamma. This study was designed to clarify the clinical characteristics of IFA and NFA and compare the therapeutic characteristics of OIT using subcutaneously administered IFN-gamma for both types of food allergy. In this study, 148 patients were categorized into the IFA and NFA group following food challenge, skin-prick test and food-specific IgE tests. The patients were then treated using protocols specific for IFA and NFA using subcutaneous IFN-gamma injection as a randomized controlled trial. The principle of complete allergy resolution at prior dose in the case of IFA was also evaluated. Only the patients with IFA and NFA treated with OIT using IFN-gamma achieved tolerance successfully. Tolerance was achieved from low-dose range in IFA and in high-dose range for NFA. Complete tolerance was not obtained without achieving complete allergy resolution at each dose of the allergen before increasing the dosage in IFA. Both IFA and NFA can be successfully treated with OIT using IFN-gamma but show different clinical and therapeutic characteristics. IFN-gamma is necessary for the tolerance induction but not for tolerance maintenance. Additional study for the mechanisms of tolerance induction by IFN-gamma is needed.
Jae Ho Lee; Geunwoong Noh; Joonyong Noh; Soojin Lee; Wahn Soo Choi; Hyuk Soon Kim; Kwangju Lee; Seonphill Choi; Hyunjung Jin; Sunheui Cho; Sangsun Lee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  31     ISSN:  1539-6304     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-09-07     Completed Date:  2011-06-14     Revised Date:  2011-08-12    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e39-e47     Citation Subset:  IM    
Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea.
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MeSH Terms
Allergens / administration & dosage*,  immunology
Child, Preschool
Clinical Protocols
Desensitization, Immunologic*
Disease-Free Survival
Drug Therapy, Combination
Food / adverse effects
Food Hypersensitivity / diagnosis,  drug therapy*,  immunology,  physiopathology
Hypersensitivity, Delayed / diagnosis,  drug therapy*,  immunology,  physiopathology
Immune Tolerance / drug effects
Immunoglobulin E / blood
Interferon-gamma / therapeutic use*
Skin Tests
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E; 82115-62-6/Interferon-gamma

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