Document Detail

Clinical characteristics of optic neuritis in Taiwanese children.
MedLine Citation:
PMID:  21852809     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To document the etiology, clinical presentation, and visual prognosis of optic neuritis in Taiwanese children.
METHODS: Retrospectively reviewed children younger than 18 years old with optic neuritis in Chang Gung Memorial Hospital and Chang Gung Children's Hospital from 1998 to 2009.
RESULTS: There were 24 children (38 eyes) with optic neuritis in that period. Overall, 14 patients (58.3%) were female and 10 patients (41.7%) were male. In total, 14 patients (58.3%) had bilateral involvement, and 10 patients (41.7%) had unilateral involvement. Out of 38 eyes, 24 (63.2%) had disc swelling. Out of 24 patients, 21 (87.5%) underwent intravenous steroid therapy (10 to 30 mg/kg/day) for 3-5 days, and followed by an oral taper. Out of 24 patients, 20 (83.3%) achieved final visual acuity (VA) of 20/40 or better. However, a poor visual outcome (four patients) (VA<20/40) was correlated with pale disc at presentation (P=0.002, Pearson χ (2)-test) and age older than 10 years (P=0.012, Fisher's exact test). Five patients were diagnosed with acute disseminated encephalomyelitis (ADEM) (21%), and three patients were diagnosed with multiple sclerosis (MS) (12.5%). Patients with ADEM did not have a better visual outcome than patients with MS (P=0.643, Fisher's exact test).
CONCLUSIONS: Visual recovery from optic neuritis was favorable in Taiwanese children. A poor visual outcome was correlated with pale disc at presentation and patients' age older than 10 years. ADEM is the most common associated systemic disease; MS is relatively rare.
M-H Sun; H-S Wang; K-J Chen; W-W Su; P-Y Hsueh; K-K Lin; L-Y Kao
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Publication Detail:
Type:  Journal Article     Date:  2011-08-19
Journal Detail:
Title:  Eye (London, England)     Volume:  25     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-01-05     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1457-64     Citation Subset:  IM    
Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
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MeSH Terms
Autoimmune Diseases of the Nervous System / complications
Child, Preschool
Optic Neuritis* / drug therapy,  etiology,  physiopathology
Retrospective Studies
Risk Factors
Visual Acuity / physiology
Erratum In:
Eye (Lond). 2011 Nov;25(11):1527-8

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