| Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. | |
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MedLine Citation:
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PMID: 21221584 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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POEMS syndrome is a rare plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. This study reviewed the clinical characteristics and long-term outcome of 99 consecutive Chinese patients with newly diagnosed POEMS syndrome in a single institute. The median age of 99 patients was 45 years, and the ratio of men/women was 1.4. The median time from onset of symptoms to diagnosis was 18 months. The typical five features of peripheral neuropathy, organomegaly, endocrinopathy, M protein, and skin change remained to be essential for patients with POEMS syndrome in China. The unusual features like pulmonary hypertension (36%) and renal impairment (37%) were not uncommon in China. Eighty-three percent patients were alive after follow-up time of 25 months, and 10% patients had survived more than 60 months. Melphalan-based therapy (OR, 0.076; 95% CI, 0.02-0.285) and normal renal function (OR, 0.246; 95% CI, 0.076-0.802) were independent prognostic factors for the survival of patients with POEMS syndrome. In conclusion, POEMS syndrome in Chinese patients was a multi-systemic disease with clinical features similar to non-Chinese ones. Active therapy can effectively improve the prognosis of patients with POEMS syndrome. |
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Authors:
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Jian Li; Dao-Bin Zhou; Zhen Huang; Li Jiao; Ming-Hui Duan; Wei Zhang; Yong-Qiang Zhao; Ti Shen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-8 |
Journal Detail:
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Title: Annals of hematology Volume: - ISSN: 1432-0584 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Hematology, Peking Union Medical College Hospital, Beijing, 100730, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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