Document Detail

Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas.
MedLine Citation:
PMID:  17303931     Owner:  NLM     Status:  MEDLINE    
In this study, we described the effectiveness of metformin on Japanese type 2 diabetes patients receiving sulfonylureas and the clinical characteristics of the patients whose glycemic control were significantly improved with metformin administration. Our results showed that the reduction of glycohemoglobin (HbA1C), serum concentration of total cholesterol, and diastolic blood pressure was statistically significant through the administration of metformin. The clinical characteristics of the patients who responded to metformin therapy exhibited lower systolic blood pressure in addition to higher HbA1C value just before administration of metformin when compared with DeltaHbA1C (HbA1C 6 months after administration of metformin--HbA1C before administration of metformin). Moreover, effectiveness of metformin was weakened, in comparison with non-hypertensive patients, even though the blood pressure of hypertensive patients was reduced to normal range by medication with antihypertensive drugs. But average reduction of HbA1C level of hypertensive patients without antihypertensive medications was smaller than those of patients with high blood pressure with such medication. These results suggested that high blood pressure and hypertension phenotype itself were suppressive factors of metformin but antihypertensive therapy itself enhanced the effectiveness of metformin regardless of the improvement of blood pressure.
Setsuko Tomioka; Hiroyasu Ogata; Yoshifumi Tamura; Tomoaki Shimizu; Hirotaka Watada; Yoshio Fujitani; Ryuzo Kawamori; Takahisa Hirose
Publication Detail:
Type:  Journal Article     Date:  2007-02-16
Journal Detail:
Title:  Endocrine journal     Volume:  54     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Clinical Pharmacy Course, Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, Japan.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Asian Continental Ancestry Group*
Blood Pressure / drug effects
Cholesterol / blood
Diabetes Mellitus, Type 2 / complications,  drug therapy*,  ethnology,  physiopathology*
Hemoglobin A, Glycosylated / metabolism
Hypertension / complications,  drug therapy
Hypoglycemic Agents / therapeutic use*
Metformin / therapeutic use*
Middle Aged
Sulfonylurea Compounds / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 57-88-5/Cholesterol; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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