Document Detail


Clinical characteristics of frontotemporal patients with symmetric brain atrophy.
MedLine Citation:
PMID:  12451466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper we explored patterns of frontal and temporal asymmetry in frontotemporal dementia (FTD) and tried to isolate clinical correlates associated with asymmetry or lack thereof. Volumes of frontal and temporal lobes, hippocampus and entorhinal cortex were measured using magnetic resonance imaging (MRI) in 10 patients with FTD. Age- and cranial size-specific values were computed through linear regression analysis (W-scores). A subgroup of 3 patients with symmetric frontal and temporal atrophy was identified. When compared to patients with asymmetric atrophy, the former had younger age at onset of the disease (p = 0.02), greater overall frontotemporal (p = 0.02) and greater entorhinal atrophy (p < 0.04). Two of the three patients were apolipoprotein E epsilon4 carriers versus none of the asymmetric patients (p = 0.02). The lack of asymmetry in this small sample of FTD patients was associated with greater brain atrophy, younger age at onset, and presence of the epsilon4 allele of apolipoprotein E. The presence of the epsilon4 allele is consistent with the hypothesis of greater vulnerability of the brain in epsilon4 carriers.
Authors:
Marina Boccardi; Mikko P Laakso; Lorena Bresciani; Cristina Geroldi; Alberto Beltramello; Giovanni B Frisoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  252     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-05-12     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Affiliation:
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, 25125 Brescia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Apolipoproteins E / metabolism*
Atrophy / complications,  metabolism,  pathology
Dementia / diagnosis*,  etiology*,  genetics
Female
Frontal Lobe / metabolism*,  pathology*
Functional Laterality / physiology
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Oximes / diagnostic use
Radiopharmaceuticals / diagnostic use
Severity of Illness Index
Temporal Lobe / metabolism*,  pathology*
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Oximes; 0/Radiopharmaceuticals; 0/hexamethylpropyleneamine oxime

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