| Clinical characteristics and four-year outcomes of patients in the Rhode Island Takotsubo Cardiomyopathy Registry. | |
| | |
MedLine Citation:
|
PMID: 19327433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim was to establish a registry of patients with a diagnosis of Takotsubo cardiomyopathy (TC) to help learn more about the characteristics, treatment strategies, and natural history of this disease. Data for patients with TC diagnosed from July 2004 to April 2008 at 2 major hospitals in Rhode Island were obtained. A data set was created that included baseline demographics and characteristics, hospital, course, and clinical outcomes. TC was diagnosed in 70 patients during the study period. Postmenopausal women comprised 95% of the cohort. Six patients presented with cardiogenic shock, 9 required intubation, 3 experienced sustained ventricular arrhythmias, and 1 patient died of cardiac causes. Average ejection fraction was 37% at cardiac catheterization. Troponin-I was increased in all except 1 patient. Follow-up echocardiography showed full recovery of wall motion abnormalities, with an average ejection fraction of 59%. Most patients were treated using standard cardiovascular medications for acute coronary syndrome, and 43% were discharged on warfarin therapy because of severe apical wall motion abnormalities. Univariate analysis suggested that long-term use of angiotensin-converting enzyme inhibitors before the onset of TC was protective against cardiogenic shock, sustained ventricular arrhythmia, and death. Consecutive cases grouped into different seasons showed a statistically significant spike in the occurrence of TC during the summer months. In conclusion, the acute phase of this condition may lead to critical illness and death, and use of an angiotensin-converting enzyme inhibitor may have a protective effect. Overall long-term prognosis and recovery of left ventricular function were excellent. |
| | |
Authors:
|
Richard A Regnante; Ryan W Zuzek; Steven B Weinsier; Syed R Latif; Russell A Linsky; Hanna N Ahmed; Immad Sadiq |
Related Documents
:
|
21106653 - Longitudinal shortening accounts for the majority of right ventricular contraction and ... 6201683 - Surgical palliation of subaortic stenosis in the univentricular heart. 20185493 - Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Multicenter Study Date: 2009-02-07 |
Journal Detail:
|
Title: The American journal of cardiology Volume: 103 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-30 Completed Date: 2009-04-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1015-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, Division of Cardiology, The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA. rregnante@lifespan.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Female Follow-Up Studies Heart Catheterization / methods* Humans Incidence Male Prognosis Recovery of Function / drug effects, physiology Registries* Retrospective Studies Rhode Island / epidemiology Severity of Illness Index Stroke Volume / physiology Survival Rate / trends Takotsubo Cardiomyopathy / diagnosis, epidemiology*, prevention & control Time Factors Ventricular Function, Left / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of left ventricular dysfunction with Tei index in normal ejection fraction patients with m...
Next Document: Usefulness of two-dimensional speckle tracking echocardiography for assessment of Tako-Tsubo cardiom...