Document Detail

Clinical characteristics and follow up of Down syndrome infants without congenital heart disease who presented with persistent pulmonary hypertension of newborn.
MedLine Citation:
PMID:  15085894     Owner:  NLM     Status:  MEDLINE    
We identified seventeen infants with Down syndrome without structural congenital heart disease who presented with persistent pulmonary hypertension in the newborn period. Respiratory distress with or without hypoxia was the presenting feature in these infants. Pulmonary hypertension resolved in the majority of the survivors. Two infants with refractory pulmonary hypertension benefited from patent ductus arteriosus ligation. Autopsies in two infants demonstrated structural lung immaturity. We suggest that infants with Down syndrome are at risk of developing persistent pulmonary hypertension even in the absence of structural heart disease and these infants should be followed up until resolution of the pulmonary hypertension.
Prakesh S Shah; Jonathan Hellmann; Ian Adatia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  32     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Division of Neonatology, Department of Critical Care, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Down Syndrome*
Follow-Up Studies
Heart Defects, Congenital
Infant, Newborn
Medical Records
Ontario / epidemiology
Persistent Fetal Circulation Syndrome / epidemiology*,  mortality,  pathology,  surgery
Retrospective Studies

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