Document Detail

Clinical characteristics of eyes demonstrating atypical patterns in scanning laser polarimetry.
MedLine Citation:
PMID:  17627289     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To characterize which clinical features are associated with the occurrence of atypical birefringence patterns (ABP) occasionally seen with scanning laser polarimetry (SLP). METHODS: Sixty-one subjects, including glaucoma patients, glaucoma suspects, and normal subjects, underwent a full clinical examination, standard visual field (VF) test, and a GDx-VCC SLP examination. One eye was selected from each patient. The magnitude of ABP was determined in two independent ways: using a support vector machine analysis (typical scan score (TSS)) and by a masked experienced observer. We assessed whether the magnitude of ABP was correlated with age, gender, the refractive state of the eye, corneal polarization axis and magnitude, GDx global parameters (TSNIT and NFI), and the VF status, as evident from glaucoma hemifield test (GHT), mean deviation (MD), and the pattern standard deviation (PSD). RESULTS: Of the 61 study eyes, 27 (44%) showed an ABP, based on a TSS cutoff (<82.5). A very high correlation was found between the TSS score and the masked experienced observer score (r(2)=0.80; P<0.001). The following clinical parameters were found, on bivariate analysis, to be significantly correlated with the presence of an ABP: age (r(2)=0.086; P=0.02); corneal polarization magnitude (r(2)=0.069; P=0.04); TSNIT (r(2)=0.16; P<0.001). CONCLUSION: The presence and magnitude of ABP did not seem to be closely correlated with most clinical parameters. A low, but statistically significant, correlation was found for age and corneal polarization magnitude (r(2)=0.086 and 0.069, respectively). A low-medium correlation was found for TSNIT (r(2)=0.16); however, we speculate that this might represent a confounding effect, rather than an underlying association. We conclude that none of the clinical parameters investigated in this study appears to be strongly correlated with the presence of an ABP on SLP scans performed using the commercially available GDx-VCC.
A Orlev; A Horani; Y Rapson; M J Cohen; E Z Blumenthal
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-13
Journal Detail:
Title:  Eye (London, England)     Volume:  22     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-06-30     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1378-83     Citation Subset:  IM    
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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MeSH Terms
Age Factors
Diagnostic Techniques, Ophthalmological / instrumentation
Glaucoma / diagnosis*
Intraocular Pressure / physiology
Lasers / diagnostic use
Nerve Fibers / physiology
Optic Disk / surgery*
Prospective Studies
Refraction, Ocular / physiology
Retinal Ganglion Cells / pathology
Sex Factors
Visual Acuity
Visual Fields / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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