| Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China. | |
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MedLine Citation:
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PMID: 22205620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The critical illness of pandemic influenza A (H1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated with the deaths of critical patients. METHODS: Medical records of 26 critical patients with H1N1 infection admitted from Sept. 1 to Dec. 31, 2009, were retrospectively reviewed. Diagnosis was established by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay. RESULTS: The mean age of the patients was (40.4 ± 18.4) years and 73.1% of them were male. Clinical manifestations included fever, cough, and sputum production. The laboratory findings included leukocytosis, lymphopenia, C-reaction protein, and lactic dehydrogenase elevation. In this series, 17 subjects survived and 9 died. The parameters between the deaths and survivors were compared, which included acute physiology and chronic health evaluation II (APACHE II) scores (23.8 ± 10.1 vs. 14.3 ± 6.6, P<0.05), sequential organ failure assessment (SOFA) scores (13.3 ± 3.0 vs. 6.6 ± 3.3, P<0.05), and multiple organ dysfunction syndrome (MODS) scores (7.4 ± 2.5 vs. 3.3 ± 1.7, P<0.05). The cases of deaths had higher incidences of cardiovascular failure (100% vs. 41.2%, P<0.05), renal failure (55.6% vs. 11.7%, P<0.05), encephalopathy (44.4% vs. 5.9%, P<0.05), hepatic failure (33.3% vs. 5.9%, P<0.05), and septic shock (33.3% vs. 17.6%, P<0.05). CONCLUSIONS: The critical patients with H1N1 infection have high APACHE II, SOFA, and MODS scores, which may be associated with an increased risk of death and complex clinical courses. |
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Authors:
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Li-hui Deng; Yi-lan Zeng; Ping Feng; Ya-ling Liu; Li-chun Wang; Yun Bai; Hong Tang |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 13 ISSN: 1862-1783 ISO Abbreviation: J Zhejiang Univ Sci B Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-29 Completed Date: 2012-04-26 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: China |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: IM |
Affiliation:
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Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Adult China / epidemiology Female Humans Influenza A Virus, H1N1 Subtype / genetics, isolation & purification* Influenza, Human / epidemiology, pathology*, virology* Male Middle Aged Multiple Organ Failure Pandemics* RNA, Viral / chemistry, genetics Real-Time Polymerase Chain Reaction Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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