Document Detail

Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China.
MedLine Citation:
PMID:  22205620     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The critical illness of pandemic influenza A (H1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated with the deaths of critical patients.
METHODS: Medical records of 26 critical patients with H1N1 infection admitted from Sept. 1 to Dec. 31, 2009, were retrospectively reviewed. Diagnosis was established by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay.
RESULTS: The mean age of the patients was (40.4 ± 18.4) years and 73.1% of them were male. Clinical manifestations included fever, cough, and sputum production. The laboratory findings included leukocytosis, lymphopenia, C-reaction protein, and lactic dehydrogenase elevation. In this series, 17 subjects survived and 9 died. The parameters between the deaths and survivors were compared, which included acute physiology and chronic health evaluation II (APACHE II) scores (23.8 ± 10.1 vs. 14.3 ± 6.6, P<0.05), sequential organ failure assessment (SOFA) scores (13.3 ± 3.0 vs. 6.6 ± 3.3, P<0.05), and multiple organ dysfunction syndrome (MODS) scores (7.4 ± 2.5 vs. 3.3 ± 1.7, P<0.05). The cases of deaths had higher incidences of cardiovascular failure (100% vs. 41.2%, P<0.05), renal failure (55.6% vs. 11.7%, P<0.05), encephalopathy (44.4% vs. 5.9%, P<0.05), hepatic failure (33.3% vs. 5.9%, P<0.05), and septic shock (33.3% vs. 17.6%, P<0.05).
CONCLUSIONS: The critical patients with H1N1 infection have high APACHE II, SOFA, and MODS scores, which may be associated with an increased risk of death and complex clinical courses.
Li-hui Deng; Yi-lan Zeng; Ping Feng; Ya-ling Liu; Li-chun Wang; Yun Bai; Hong Tang
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  13     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-29     Completed Date:  2012-04-26     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
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MeSH Terms
China / epidemiology
Influenza A Virus, H1N1 Subtype / genetics,  isolation & purification*
Influenza, Human / epidemiology,  pathology*,  virology*
Middle Aged
Multiple Organ Failure
RNA, Viral / chemistry,  genetics
Real-Time Polymerase Chain Reaction
Retrospective Studies
Reg. No./Substance:
0/RNA, Viral

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