Document Detail

Clinical characteristics, ballooning pattern, and long-term prognosis of transient left ventricular ballooning syndrome.
MedLine Citation:
PMID:  20457338     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although patients with transient left ventricular ballooning syndrome (TLVBS), also known as Takotsubo cardiomyopathy, improve rapidly and recover left ventricular systolic function, the long-term prognosis is not well-known. This study investigated the clinical features of TLVBS, and its in-hospital and long-term (in-hospital plus postdischarge) mortality.
METHODS AND RESULTS: We evaluated 87 patients diagnosed with TLVBS. The median follow-up was 42 months (interquartile range, 19 to 72 months). During follow-up, no recurrences were reported, but 20 (23%) patients died. Two nonsurvivors (2%) were suspected of dying from sudden cardiac death. The in-hospital total mortality rate was 9%, but the in-hospital cardiac mortality rate was 0%. Most deaths were associated with underlying noncardiac diseases. Baseline characteristics were mostly similar between survivors and nonsurvivors. However, nonsurvivors were older, and more likely to be smokers compared with survivors. Underlying noncardiac diseases were the only independent predictors of long-term mortality (hazard ratio, 3.954; 95% confidence interval, 1.369 to 11.422; P=.011). There were no significant differences in long-term mortality, according to the preceding stress events or ballooning patterns.
CONCLUSIONS: Although a substantial number of patients with TLVBS die, the long-term cardiac mortality is low. The severity of heart failure owing to TLVBS may influence in-hospital mortality, whereas underlying noncardiac diseases have a more significant correlation with the long-term prognosis than does TLVBS itself.
Bong Gun Song; Joo-Yong Hahn; Soo Jin Cho; Young Hwan Park; Seung Min Choi; Ji Han Park; Seung-Hyuk Choi; Jin-Ho Choi; Seung Woo Park; Sang Hoon Lee; Hyeon-Cheol Gwon
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Publication Detail:
Type:  Journal Article     Date:  2009-10-02
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  39     ISSN:  1527-3288     ISO Abbreviation:  Heart Lung     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-05-11     Completed Date:  2011-06-02     Revised Date:  2011-10-13    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea.
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MeSH Terms
Age Factors
Aged, 80 and over
Confidence Intervals
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Republic of Korea
Retrospective Studies
Risk Factors
Severity of Illness Index
Takotsubo Cardiomyopathy / diagnosis*,  mortality,  pathology
Time Factors
Comment In:
Heart Lung. 2011 Sep-Oct;40(5):472   [PMID:  20723983 ]

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